Signaling interplay between primary cilia and nitric oxide: A mini review.

Signaling interplay between primary cilia and nitric oxide: A mini review.
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DOI:
10.1016/j.niox.2018.08.003
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发表时间:
2018-11-01
期刊:
Nitric oxide : biology and chemistry
影响因子:
--
通讯作者:
AbouAlaiwi WA
AbouAlaiwi WA
中科院分区:
其他
文献类型:
--
作者:
Saternos HC;AbouAlaiwi WA

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New discoveries into the functional role of primary cilia are on the rise. In little more than 20 years, research has shown the once vestigial organelle is a signaling powerhouse involved in a vast number of essential cellular processes. In the same decade that interest in primary cilia was burgeoning, nitric oxide won molecule of the year and a Nobel prize for its role as a near ubiquitous signaling molecule. Although primary cilia and nitric oxide are both involved in signaling, a direct relationship has not been investigated; however, after a quick review of the literature, parallels between their functions can be drawn. This review aims to suggest a possible interplay between primary cilia and nitric oxide signaling especially in the areas of vascular tissue homeostasis and cellular proliferation.
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