Nosocomial pneumonia: pathogenesis and recent advances in diagnosis and therapy.

Nosocomial pneumonia: pathogenesis and recent advances in diagnosis and therapy.
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院内肺炎:发病机制及诊断和治疗的最新进展。

DOI:
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发表时间:
1991
期刊:
Reviews of Infectious Diseases
影响因子:
--
通讯作者:
G. Mandell
G. Mandell
中科院分区:
--
文献类型:
--
作者:
W. Scheld;G. Mandell

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尽管最近在预防和治疗医院获得性感染方面取得了进展,但医院获得性肺炎仍然是危重患者中的一个重要问题。每1,000名住院患者中有5至10名患者发生院内肺炎,死亡率为20%-50%。本文就近年来医院获得性肺炎的三个研究领域作一综述:(1)发病机制,特别是革兰阴性杆菌在胃内定植在咽部逆行扩散中的作用;(2)诊断,特别是支气管肺泡灌洗和支气管镜检查时保护标本刷的方法;(3)超广谱青霉素类、第三代头孢菌素类、亚胺培南、氨曲南、喹诺酮类药物治疗。
Despite recent progress in the prevention and treatment of hospital-acquired infections, nosocomial pneumonia remains an important problem among critically ill patients. Nosocomial pneumonia develops in five to 10 patients per 1,000 admissions and has a mortality rate of 20%-50%. This review focuses on three areas of nosocomial pneumonia that have been the subject of investigation in recent years: (1) pathogenesis, especially the role of gastric colonization with gram-negative bacilli in retrograde pharyngeal spread; (2) diagnosis, particularly by means of bronchoalveolar lavage and the protected specimen brush during bronchoscopy; and (3) therapy with extended-spectrum penicillins, third-generation cephalosporins, imipenem, aztreonam, and quinolones.
唾液蛋白酶活性在革兰氏阴性杆菌与哺乳动物口腔上皮细胞体内粘附中的作用。
DOI: 10.1172/jci110395
发表时间: 1981
期刊: The Journal of clinical investigation
影响因子: --
作者:
Woods,DE;Straus,DC;JohansonJr,WG;Bass,JA
通讯作者: Bass,JA
DOI: 10.1093/infdis/155.5.855
发表时间: 1987-05-01
影响因子: 6.4
作者:
THORPE, JE;BAUGHMAN, RP;STANECK, JL
通讯作者: STANECK, JL
DOI: 10.1164/arrd.1982.125.1.53
发表时间: 1982
期刊: The American review of respiratory disease
影响因子: --
作者:
Higuchi,JH;Coalson,JJ;JohansonJr,WG
通讯作者: JohansonJr,WG