Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis.
Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis.
复制标题
DOI：
10.1016/j.jcf.2012.04.006
复制
发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Tran D
中科院分区：
文献类型：
--
作者：
Asner S;Waters V;Solomon M;Yau Y;Richardson SE;Grasemann H;Gharabaghi F;Tran D
呼吸道病毒在囊性纤维化（CF）恶化中的作用尚不完全清楚。CF患儿合并肺加重的横断面研究。中鼻甲拭子采用直接免疫荧光抗体试验和多重PCR检测板（ResPlex II v2.0, Qiagen）进行检测。Resplex II也应用于痰液或咽拭子样本。记录肺功能检查、生活质量和严重程度评分。测定痰细胞计数、细菌密度和细胞因子。通过适用于任何样本类型的任何诊断方法，26/43（60.5%）受试者至少对一种呼吸道病毒检测呈阳性。病毒阳性患者较年轻（p = 0.047），男性多（p = 0.029）， CF临床严重程度较高（p = 0.041），生活质量（身体）评分较低（p = 0.023），但IL-8、中性粒细胞百分比和弹性蛋白酶水平相似。与非病毒性恶化相比，病毒相关恶化与更差的严重程度和生活质量评分相关，但与肺部炎症相似。
The role of respiratory viruses in cystic fibrosis (CF) exacerbations is incompletely understood. Cross-sectional study of CF children with a pulmonary exacerbation. Mid-turbinate swabs were tested by a direct immunofluorescent antibody assay and a multiplex PCR panel (ResPlex II v2.0, Qiagen). Resplex II was also applied to sputum or throat swab samples. Pulmonary function tests and quality of life and severity scores were recorded. Sputum cell counts, bacterial density and cytokines were measured. 26/43 (60.5%) subjects tested positive for at least one respiratory virus by any diagnostic method applied to any sample type. Virus-positive patients were younger (p = 0.047), more likely to be male (p = 0.029), and had higher CF clinical severity (p = 0.041) and lower quality of life (physical) scores (p = 0.023) but similar IL-8, neutrophil percentage and elastase levels. Compared to non-viral exacerbations, viral-related exacerbations were associated with worse severity and quality of life scores but similar pulmonary inflammation.
登录
查看更多内容
影响因子：
5.2
作者：
SMYTH, AR;SMYTH, RL;HEAF, DP
通讯作者：
HEAF, DP
DOI：
10.1164/rccm.200609-1354oc
发表时间：
2007-04-15
影响因子：
24.7
作者：
Mayer-Hamblett, Nicole;Aitken, Moira L.;Ramsey, Bonnie W.
通讯作者：
Ramsey, Bonnie W.
影响因子：
3.2
作者：
Kanga, J;Kuhn, R;Church, D
通讯作者：
Church, D
影响因子：
8
作者：
van Ewijk, Bart E.;van der Zalm, Marieke M.;van der Ent, Cornelis K.
通讯作者：
van der Ent, Cornelis K.
影响因子：
4.4
作者：
Burns, Jane L.;Emerson, Julia;Englund, Janet A.
通讯作者：
Englund, Janet A.