An endogenous opioid circuit determines state-dependent reward consumption.
An endogenous opioid circuit determines state-dependent reward consumption.
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DOI：
10.1038/s41586-021-04013-0
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发表时间：
2021-10
期刊：
影响因子：
64.8
通讯作者：
Bruchas MR
中科院分区：
文献类型：
--
作者：
Castro DC;Oswell CS;Zhang ET;Pedersen CE;Piantadosi SC;Rossi MA;Hunker AC;Guglin A;Morón JA;Zweifel LS;Stuber GD;Bruchas MR
Mu-opioid peptide receptor (MOPR) stimulation alters respiration, analgesia, and reward behavior, and can induce substance abuse and overdose. Despite its evident importance, the endogenous mechanisms for MOPR regulation of consummatory behavior have remained unknown. Here we report that endogenous MOPR regulation of reward consumption in mice acts through a specific dorsal raphe to nucleus accumbens projection. MOPR-mediated inhibition of raphe terminals is necessary and sufficient to determine consummatory response while select enkephalin-containing NAc ensembles are engaged prior to reward consumption, suggesting that local enkephalin release is the source of endogenous MOPR ligand. Selective modulation of NAc enkephalin neurons and CRISPR-Cas9-mediated disruption of enkephalin substantiate this finding. These results isolate a fundamental endogenous opioid circuit for state-dependent consumptive behavior and suggest alternative mechanisms for opiate modulation of reward.
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DOI：
10.1523/jneurosci.3216-18.2021
发表时间：
2021-03-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fetterly TL;Oginsky MF;Nieto AM;Alonso-Caraballo Y;Santana-Rodriguez Z;Ferrario CR
通讯作者：
Ferrario CR
影响因子：
64.8
作者：
HUGHES, J;SMITH, TW;MORRIS, HR
通讯作者：
MORRIS, HR
影响因子：
2.9
作者：
BODNAR, RJ;GLASS, MJ;COOPER, ML
通讯作者：
COOPER, ML
影响因子：
7.7
作者：
Al-Hasani R;Wong JT;Mabrouk OS;McCall JG;Schmitz GP;Porter-Stransky KA;Aragona BJ;Kennedy RT;Bruchas MR
通讯作者：
Bruchas MR
影响因子：
8.8
作者：
Hunker, Avery C.;Soden, Marta E.;Zweifel, Larry S.
通讯作者：
Zweifel, Larry S.