HBV pregenome RNA as a predictor of spontanous HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients.
HBV pregenome RNA as a predictor of spontanous HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients.
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HBV 前基因组 RNA 作为 HBeAg 阳性慢性乙型肝炎患者自发 HBeAg 血清转化的预测因子。
DOI：
10.1186/s12876-023-03023-8
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发表时间：
2023-11-09
影响因子：
2.4
通讯作者：
Xie, Yandi
中科院分区：
文献类型：
--
作者：
Song, Guangjun;Yang, Ruifeng;Jin, Qian;Liu, Juan;Rao, Huiying;Feng, Bo;Xie, Yandi
既往研究表明，HBV前基因组RNA（HBV pgRNA）可预测慢性乙型肝炎（CHB）患者经聚乙二醇干扰素（Peg-IFN）或核苷类似物（NAs）治疗后HBeAg血清转换。然而，关于HBV pgRNA预测自发性HBeAg血清转换的数据有限。对113例免疫活跃期HBeAg阳性的慢性乙型肝炎患者进行了为期76周的随访，未进行抗病毒治疗。根据第76周肝功能、HBeAg、抗-HBe和HBV DNA的实验室检查结果，将患者分为两组：自发HBeAg血清转换组（A组，n = 18）和非自发HBeAg血清转换组。对照组（B组，n = 36）。第12周时，A组和B组之间HBV pgRNA水平差异有统计学意义（A组6.35 ± 1.24 log 10 copies/ml，B组B 7.52 ± 0.79 log 10 copies/ml，P = 0.001），第28周差异扩大。第28周HBV pgRNA水平和HBV pgRNA水平的受试者工作特征曲线（AUROC）分别为0.912（P = 0.001，95%CI：0.830-0.994）和0.934（P = 0.001，95%CI：0.872-0.996）。预测自发性HBeAg血清转换的最佳截止值HBV pgRNA和第28周较基线降低值（HBV pgRNA）分别为5.63 log 10拷贝/ml和1.85 log 10拷贝/ml。28周时HBV pgRNA阳性预测值为86.7%，阴性预测值为87.2%; HBV pgRNA阴性预测值为87.5%，阴性预测值为89.5%。结合HBV pgRNA水平和HBV pgRNA下降可以提供更好的预测。HBV pgRNA是慢性乙型肝炎免疫活动期患者HBeAg自发血清转换的可靠预测指标。动态监测HBV pgRNA有助于临床治疗决策。
Previous studies have indicated that HBV pregenome RNA (HBV pgRNA) could predict HBeAg seroconversion among the chronic hapatitis B (CHB) patients treated with pegylated interferon (Peg-IFN) or nucleos(t)ide analogues (NAs). However, the data about the prediction of HBV pgRNA for spontaneous HBeAg seroconversion is limited. One hundred thirteen CHB patients with HBeAg-positive in the immune active phase were followed up for 76 weeks without antiviral treatment. Based on the laboratory test results of liver function, HBeAg, anti-HBe, and HBV DNA at week 76, patients were assigned to two groups: spontaneous HBeAg seroconversion (group A, n = 18) and non-spontaneous HBeAg seroconversion group. Among the latter group, 36 patients were selected as controls (group B, n = 36). At week 12, between group A and group B, there was a significant difference in the level of HBV pgRNA (group A 6.35 ± 1.24 log10 copies/ml and group B 7.52 ± 0.79 log10 copies/ml, P = 0.001), and the difference enlarged at week 28. The receiver operating characteristic curves (AUROCs) of the HBV pgRNA level and the ∆HBV pgRNA at week 28 were 0.912 (P = 0.001, 95% CI: 0.830–0.994), and 0.934 (P = 0.001, 95% CI: 0.872–0.996), respectively. The optimal cutoffs of HBV pgRNA and the reduction from baseline (∆HBV pgRNA) at week 28 for spontaneous HBeAg seroconversion prediction were 5.63 log10 copies/ml and 1.85 log10 copies/ml, respectively. The positive predictive value and negative predictive value of HBV pgRNA and ∆HBV pgRNA at week 28 were 86.7% and 87.2%, 87.5% and 89.5%, respectively. And the combination of the HBV pgRNA level and the HBV pgRNA decreased could provide better prediction. HBV pgRNA is a sound predictor for spontaneous HBeAg seroconversion among the CHB patients in immune active phase. Dynamic monitoring of HBV pgRNA is helpful for clinical treatment decision.
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血清 HBV RNA：慢性乙型肝炎病毒感染的新的潜在生物标志物
DOI：
10.1002/hep.30325
发表时间：
2019-04
期刊：
Hepatology (Baltimore, Md.)
影响因子：
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