Homeostatic circuits selectively gate food cue responses in insular cortex.
Homeostatic circuits selectively gate food cue responses in insular cortex.
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DOI：
10.1038/nature22375
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发表时间：
2017-06-29
期刊：
影响因子：
64.8
通讯作者：
Andermann ML
中科院分区：
文献类型：
--
作者：
Livneh Y;Ramesh RN;Burgess CR;Levandowski KM;Madara JC;Fenselau H;Goldey GJ;Diaz VE;Jikomes N;Resch JM;Lowell BB;Andermann ML
生理需要偏向感知和注意相关的感官线索。这个过程被药物成瘾“劫持”，导致线索诱导的渴望和复发。同样，它的失调导致失败的饮食，肥胖和饮食失调。人类的神经影像学研究表明，这些现象与岛叶皮层有关。然而，它仍然不清楚如何“认知”皮层代表动机相关的线索是偏置的皮层下电路，驱动特定的动机状态。在这里，我们开发了一种基于微棱镜的细胞成像方法，以监测视觉线索在岛叶皮层的行为小鼠在饥饿状态下的反应。岛叶皮层神经元表现出食物线索偏向的反应，在饱腹感期间被消除。出乎意料的是，虽然多个与饱腹感相关的内脏信号在岛叶皮层中会聚，但下丘脑“饥饿神经元”（表达刺鼠相关肽（AgRP））的化学发生激活绕过这些信号以恢复岛叶皮层中的饥饿样反应模式。电路映射和路径特异性操作揭示了从AgRP神经元通过室旁丘脑和基底外侧杏仁核到岛叶皮质的通路。这些结果揭示了动机相关线索的状态特异性偏见处理的神经基础。
Physiological needs bias perception and attention to relevant sensory cues. This process is ‘hijacked’ by drug addiction, causing cue-induced cravings and relapse. Similarly, its dysregulation contributes to failed diets, obesity, and eating disorders. Neuroimaging studies in humans have implicated insular cortex in these phenomena. However, it remains unclear how ‘cognitive’ cortical representations of motivationally relevant cues are biased by subcortical circuits that drive specific motivational states. Here we develop a microprism-based cellular imaging approach to monitor visual cue responses in the insular cortex of behaving mice across hunger states. Insular cortex neurons demonstrate food- cue-biased responses that are abolished during satiety. Unexpectedly, while multiple satiety-related visceral signals converge in insular cortex, chemogenetic activation of hypothalamic ‘hunger neurons’ (expressing agouti-related peptide (AgRP)) bypasses these signals to restore hunger-like response patterns in insular cortex. Circuit mapping and pathway-specific manipulations uncover a pathway from AgRP neurons to insular cortex via the paraventricular thalamus and basolateral amygdala. These results reveal a neural basis for state-specific biased processing of motivationally relevant cues.
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影响因子：
2.5
作者：
CECHETTO, DF;SAPER, CB
通讯作者：
SAPER, CB
影响因子：
15.9
作者：
Krashes, Michael J.;Koda, Shuichi;Lowell, Bradford B.
通讯作者：
Lowell, Bradford B.
食物的感官检测快速调节弧形喂食电路。
影响因子：
64.5
作者：
Chen Y;Lin YC;Kuo TW;Knight ZA
通讯作者：
Knight ZA
影响因子：
3.4
作者：
Aronoff, Rachel;Matyas, Ferenc;Petersen, Carl C. H.
通讯作者：
Petersen, Carl C. H.
DOI：
10.1073/pnas.0708927105
发表时间：
2008-03-11
影响因子：
11.1
作者：
Accolla, Riccardo;Carleton, Alan
通讯作者：
Carleton, Alan