Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy.
Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy.
复制标题
DOI：
10.1007/s40820-019-0292-y
复制
发表时间：
2019-07-23
影响因子：
26.6
通讯作者：
Wu A
中科院分区：
文献类型：
--
作者：
Jiang Z;Yuan B;Qiu N;Wang Y;Sun L;Wei Z;Li Y;Zheng J;Jin Y;Li Y;Du S;Li J;Wu A
制备了具有高载药量和磁共振成像（MRI）的锰-沸石咪唑骨架（Mn-ZIF-90）。新设计的pH保护和主动靶向Y1受体配体的修饰减少了血液循环期间的药物释放，并特异性靶向肿瘤部位，提高了体内治疗效果。纳米尺寸的Mn-ZIF-90和高度特异性的Y1受体配体的组合促进了肿瘤部位的特异性药物积累。本文的在线版本（10.1007/s40820-019-0292-y）包含补充材料，可供授权用户使用。沸石咪唑骨架作为一种具有微环境触发释放功能的智能药物载体系统，在肿瘤治疗中受到广泛关注。然而，ZIF在生物医学中的探索仍然遇到许多问题，例如不方便的表面修饰、血液循环期间的快速药物释放、对主要器官的不期望的损伤以及严重的体内毒性。为了解决上述问题，我们开发了一种Mn-ZIF-90纳米系统，其用最初设计的主动靶向和pH响应性磁共振成像（MRI）Y1受体配体[Asn 28，Pro30，Trp 32]-NPY（25-36）功能化，用于成像引导的肿瘤治疗。在Y1受体配体修饰后，Mn-ZIF-90纳米系统表现出高载药量、更好的血液循环稳定性以及乳腺癌细胞膜和线粒体的双重靶向性，进一步有利于特定微环境触发的肿瘤治疗。同时，这种纳米系统在肿瘤部位的体内T1加权磁共振成像对比度显示出前景。特别是这种快速清除的纳米系统几乎没有明显的毒性，对小鼠的主要器官没有损害。因此，这种纳米系统显示出在成像引导的肿瘤治疗中的潜力。 本文的在线版本（10.1007/s40820-019-0292-y）包含补充材料，可供授权用户使用。
Manganese-zeolitic imidazolate frameworks (Mn-ZIF-90) with both high drug loading and magnetic resonance imaging (MRI) in vitro and in vivo were prepared. The modification of a newly designed pH-protective and active-targeting Y1 receptor ligand reduces the drug release during blood circulation and specifically targets the tumor sites, improving therapeutic efficacy in vivo. The combination of nano-size Mn-ZIF-90 and the highly specific Y1 receptor ligand promotes the specific drug accumulation in tumor sites. The online version of this article (10.1007/s40820-019-0292-y) contains supplementary material, which is available to authorized users. Zeolitic imidazolate frameworks (ZIFs) as smart drug delivery systems with microenvironment-triggered release have attracted much attention for tumor therapy. However, the exploration of ZIFs in biomedicine still encounters many issues, such as inconvenient surface modification, fast drug release during blood circulation, undesired damage to major organs, and severe in vivo toxicity. To address the above issues, we developed an Mn-ZIF-90 nanosystem functionalized with an originally designed active-targeting and pH-responsive magnetic resonance imaging (MRI) Y1 receptor ligand [Asn28, Pro30, Trp32]-NPY (25–36) for imaging-guided tumor therapy. After Y1 receptor ligand modification, the Mn-ZIF-90 nanosystem exhibited high drug loading, better blood circulation stability, and dual breast cancer cell membrane and mitochondria targetability, further favoring specific microenvironment-triggered tumor therapy. Meanwhile, this nanosystem showed promising T1-weighted magnetic resonance imaging contrast in vivo in the tumor sites. Especially, this nanosystem with fast clean-up had almost no obvious toxicity and no damage occurred to the major organs in mice. Therefore, this nanosystem shows potential for use in imaging-guided tumor therapy. The online version of this article (10.1007/s40820-019-0292-y) contains supplementary material, which is available to authorized users.
登录
查看更多内容
利用肿瘤微环境增强抗癌治疗的纳米颗粒设计策略
影响因子：
46.2
作者：
Dai Y;Xu C;Sun X;Chen X
通讯作者：
Chen X
影响因子：
4.6
作者：
Fei, Honghan;Cahill, John F.;Cohen, Seth M.
通讯作者：
Cohen, Seth M.
神经肽 Y 受体：癌症成像和治疗的一个有前途的靶点。
影响因子：
6.7
作者：
Li J;Tian Y;Wu A
通讯作者：
Wu A
影响因子：
14
作者：
Jiang, Zhenqi;Tian, Yuchen;Wu, Aiguo
通讯作者：
Wu, Aiguo
双 ATP 和 pH 响应型 ZIF-90 纳米系统具有良好的生物相容性和易于后修饰，可改善三阴性乳腺癌的体内治疗效果
影响因子：
14
作者：
Jiang, Zhenqi;Wang, Yinjie;Wu, Aiguo
通讯作者：
Wu, Aiguo