The Endothelial Junction
The Endothelial Junction
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内皮连接
DOI：
--
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
H. Kapprell
中科院分区：
文献类型：
--
作者：
W. Franke;P. Cowin;C. Grund;C. Kuhn;H. Kapprell
大多数血管的内皮是单层紧密堆积的细胞，其排列在血管腔中并与基底层相邻，并且在一些动脉和小动脉中，与血管平滑肌细胞的突起相邻。与单层上皮细胞一样，内皮细胞是极性的，具有顶端，即，近腔的，和基底的，即，腔外的质膜区域，它们似乎被包含阻塞的特殊膜区域彼此隔离，即，“紧密”连接（参见参考文献89）。同样类似于极上皮，内皮能够进行载体分选、分泌和病毒出芽以及内吞和转胞吞过程（例如参见参考文献104）。47、66、72）。显然，内皮细胞彼此紧密密封是其生理功能的先决条件，并且内皮层的连贯性局部和/或暂时中断的情况通常与病理过程（例如，参考文献16，17，52，54，77，86，92）。阐明“内皮连接”的分子组织对于我们理解内皮细胞的细胞间粘附的结构和分子是至关重要的。该连接区的特征是相邻质膜相对紧密并置，其两侧是所谓的皮质细胞质“旁连接区”（定义见参考文献90）。到目前为止，只有两个特定的路口已确定在这个交界复杂。这些是闭塞（紧密）连接和交通（间隙）连接，它们在形态上与其他组织中存在的连接相似（在参考文献中综述）。89-92;对于某些冷冻切割方面也见参考文献。98，110）。典型的桥粒或其他粘附连接结构尚未在高等脊椎动物中得到证实。然而，Fawcett 29岁，30岁，
The endothelium of most blood vessels is a single layer of tightly packed cells which line the vascular lumen and border on the basal lamina and, in some arteries and arterioles, on the processes of vascular smooth muscle cells. Like singlelayered epithelia, the endothelial cells are polar, with an apical, i.e., adluminal, and a basal, i.e., abluminal, plasma membrane region which appear to be segregated from each other by a special membrane region containing occluding, i.e., “tight,” junctions (for reviews see Ref. 89). Again similarly to polar epithelia, the endothelium is capable of vectorial sorting, secretion, and virus budding as well as endocytotic and transcytotic processes (for examples see Refs. 47,66,72). Obviously, tight sealing of endothelial cells to each other is a prerequisite for their physiological functioning, and situations in which the coherence of the endothelial layer is locally and/or transiently interrupted are usually associated with pathological processes (e.g., Refs. 16,17,52,54,77,86,92). The elucidation of the molecular organization of the “endothelial junction” is crucial to our understanding of the structures and molecules involved in the intercellular adhesion of the endothelial cells. This junctional zone is characterized by a relatively close apposition of the adjacent plasma membranes which are flanked by a so-called “parajunctional zone” of cortical cytoplasm (for definition see Ref. 90). So far only two specific junctions have been identified within this junctional complex. These are the occluding (tight) and the communicating (gap) junctions which are morphologically similar to those present in other tissues (reviewed in Refs. 89-92; for certain freeze-cleave aspects see also Refs. 98,110). Typical desmosomes or other adhering junction structures have not been demonstrated in higher vertebrates. However, Fawcett29,30 has attracted attention to
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DOI：
10.1083/jcb.99.1.95s
发表时间：
1984
期刊：
The Journal of cell biology
影响因子：
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作者：
Mangeat,P;Burridge,K
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
GIMBRONE, MA
DOI：
--
发表时间：
1986
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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作者：
R. Moll;P. Cowin;H. Kapprell;W. Franke
通讯作者：
R. Moll;P. Cowin;H. Kapprell;W. Franke
DOI：
--
发表时间：
1983
期刊：
The American journal of pathology
影响因子：
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作者：
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通讯作者：
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影响因子：
3.7
作者：
Sealock,R;Paschal,B;Beckerle,M;Burridge,K
通讯作者：
Burridge,K