Filarial infection suppresses malaria-specific multifunctional Th1 and Th17 responses in malaria and filarial coinfections.
Filarial infection suppresses malaria-specific multifunctional Th1 and Th17 responses in malaria and filarial coinfections.
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DOI：
10.4049/jimmunol.1003778
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发表时间：
2011-04-15
期刊：
影响因子：
--
通讯作者：
Nutman TB
中科院分区：
文献类型：
--
作者：
Metenou S;Dembele B;Konate S;Dolo H;Coulibaly YI;Diallo AA;Soumaoro L;Coulibaly ME;Coulibaly SY;Sanogo D;Doumbia SS;Traoré SF;Mahanty S;Klion A;Nutman TB
The mechanisms underlying the modulation of both the malaria-specific immune response and the course of clinical malaria in the context of concomitant helminth infection are poorly understood. We used multiparameter flow cytometry to characterize the quality and the magnitude of malaria-specific T cell responses in filaria-infected and -uninfected individuals with concomitant asymptomatic Plasmodium falciparum malaria in Mali. In comparison with filarial-uninfected subjects, filarial infection was associated with higher ex vivo frequencies of CD4+ cells producing IL-4, IL-10, and IL-17A (p = 0.01, p = 0.001, and p = 0.03, respectively). In response to malaria Ag stimulation, however, filarial infection was associated with lower frequencies of CD4+ T cells producing IFN-γ, TNF-α, and IL-17A (p < 0.001, p = 0.04, and p = 0.04, respectively) and with higher frequencies of CD4+IL10+T cells (p = 0.0005). Importantly, filarial infection was associated with markedly lower frequencies of malaria Ag-specific Th1 (p < 0.0001), Th17 (p = 0.012), and “TNF-α” (p = 0.0008) cells, and a complete absence of malaria-specific multifunctional Th1 cells. Filarial infection was also associated with a marked increase in the frequency of malaria-specific adaptive regulatory T/Tr1 cells (p = 0.024), and the addition of neutralizing anti–IL-10 Ab augmented the amount of Th1-associated cytokine produced per cell. Thus, among malaria-infected individuals, concomitant filarial infection diminishes dramatically the frequencies of malaria-specific Th1 and Th17 T cells, and alters the quality and magnitude of malaria-specific T cell responses.
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影响因子：
5.5
作者：
Elias, Daniel;Britton, Sven;Akuffo, Hannah
通讯作者：
Akuffo, Hannah
DOI：
10.4269/ajtmh.1991.45.65
发表时间：
1991-07-01
影响因子：
3.3
作者：
BAIRD, JK;JONES, TR;MASBAR, S
通讯作者：
MASBAR, S
影响因子：
11.8
作者：
D'Ombrain, Marthe C.;Robinson, Leanne J.;Schofield, Louis
通讯作者：
Schofield, Louis
影响因子：
3.1
作者：
Cooper, PJ;Chico, M;Nutman, TB
通讯作者：
Nutman, TB
影响因子：
3.7
作者：
Aagaard C;Hoang TT;Izzo A;Billeskov R;Troudt J;Arnett K;Keyser A;Elvang T;Andersen P;Dietrich J
通讯作者：
Dietrich J