Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.
Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.
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DOI：
10.1016/j.pbb.2012.07.007
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发表时间：
2012-11
影响因子：
3.6
通讯作者：
Lumeng, Lawrence
中科院分区：
文献类型：
--
作者：
Bell, Richard L.;Sable, Helen J. K.;Colombo, Giancarlo;Hyytia, Petri;Rodd, Zachary A.;Lumeng, Lawrence
关键词：
这篇综述文章的目的是提供证据，证明酒精中毒的大鼠动物模型为开发和筛选针对酒精滥用和依赖的药物提供了理想的平台。重点放在5个最古老的国际大鼠品系上，这些品系是为高酒精消费表型而选择性培育的。回顾了这些大鼠品系的行为和神经化学表型，并将其置于临床文献的背景下。本文介绍了用于评估药物治疗啮齿动物酒精滥用和依赖的有效性的行为模型，特别是以大鼠为重点。总结了在减少酒精/乙醇消耗和/或自我给药方面通过这些大鼠品系测试的有效性的药物及其假定的作用部位。文章还提出了针对酒精滥用和依赖的药物治疗发展的一些当前和未来的方向。
The purpose of this review paper is to present evidence that rat animal models of alcoholism provide an ideal platform for developing and screening medications that target alcohol abuse and dependence. The focus is on the 5 oldest international rat lines that have been selectively bred for a high alcohol-consumption phenotype. The behavioral and neurochemical phenotypes of these rat lines are reviewed and placed in the context of the clinical literature. The paper presents behavioral models for assessing the efficacy of pharmaceuticals for the treatment of alcohol abuse and dependence in rodents, with particular emphasis on rats. Drugs that have been tested for their effectiveness in reducing alcohol/ethanol consumption and/or self-administration by these rat lines and their putative site of action are summarized. The paper also presents some current and future directions for developing pharmacological treatments targeting alcohol abuse and dependence.
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DOI：
10.1111/j.1530-0277.2009.01031.x
发表时间：
2009-11
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Arolfo MP;Overstreet DH;Yao L;Fan P;Lawrence AJ;Tao G;Keung WM;Vallee BL;Olive MF;Gass JT;Rubin E;Anni H;Hodge CW;Besheer J;Zablocki J;Leung K;Blackburn BK;Lange LG;Diamond I
通讯作者：
Diamond I
影响因子：
2.3
作者：
Agabio, R;Carai, MAM;Colombo, G
通讯作者：
Colombo, G
影响因子：
7.3
作者：
Adams, C. L.;Short, J. L.;Lawrence, A. J.
通讯作者：
Lawrence, A. J.
DOI：
10.1111/j.1530-0277.2003.tb04413.x
发表时间：
2003-06-01
影响因子：
3.2
作者：
Badia-Elder, NE;Stewart, RB;Li, TK
通讯作者：
Li, TK
影响因子：
5
作者：
Bäckström, P;Hyytiä, P
通讯作者：
Hyytiä, P