Motor actions are spatially organized in motor and dorsal premotor cortex.
Motor actions are spatially organized in motor and dorsal premotor cortex.
复制标题
运动动作是在运动和背前皮层中空间组织的。
DOI：
10.7554/elife.83196
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发表时间：
2023-10-19
期刊：
影响因子：
7.7
通讯作者：
Gharbawie OA
中科院分区：
文献类型：
--
作者：
Chehade NG;Gharbawie OA
额叶运动区是控制随意运动的中心。在非人灵长类动物中，运动区包含独立的、躯体定位的前肢表征（即，电机图）。但是，在这些前肢表征中，行为的神经代码是否在空间上组织起来？解决这个问题将提供深入了解皮质运动系统的结构-功能关系。在这里，我们使用高分辨率光学成像和运动映射在运动（M1）和背侧运动前区（PMD）皮层的问题。两个猕猴进行了指示达到掌握任务，而皮质活动记录与内在信号光学成像（ISOI）。M1和PMd的活动的空间范围，然后量化的前肢运动地图，我们从同一半球与皮质内微刺激。ISOI表明，任务相关的活动集中在斑块，共同重叠<40%的M1和PMd前肢代表。尽管前肢的使用有很小的变化，但任务条件下的补丁的空间组织是一致的。然而，前肢使用的最大条件差异反映在皮层活动的幅度。不同的时间进程配置文件从补丁在手臂区和补丁在手区表明功能的差异内前肢的代表。这些结果共同支持了一个组织框架，其中前肢表示包含丰富的分区与神经元调整特定的行动。因此，经常被忽视的空间维度的神经活动似乎是一个重要的组织功能的神经代码在额叶运动区。
Frontal motor areas are central to controlling voluntary movements. In non-human primates, the motor areas contain independent, somatotopic, representations of the forelimb (i.e., motor maps). But are the neural codes for actions spatially organized within those forelimb representations? Addressing this question would provide insight into the poorly understood structure–function relationships of the cortical motor system. Here, we tackle the problem using high-resolution optical imaging and motor mapping in motor (M1) and dorsal premotor (PMd) cortex. Two macaque monkeys performed an instructed reach-to-grasp task while cortical activity was recorded with intrinsic signal optical imaging (ISOI). The spatial extent of activity in M1 and PMd was then quantified in relation to the forelimb motor maps, which we obtained from the same hemisphere with intracortical microstimulation. ISOI showed that task-related activity was concentrated in patches that collectively overlapped <40% of the M1 and PMd forelimb representations. The spatial organization of the patches was consistent across task conditions despite small variations in forelimb use. Nevertheless, the largest condition differences in forelimb use were reflected in the magnitude of cortical activity. Distinct time course profiles from patches in arm zones and patches in hand zones suggest functional differences within the forelimb representations. The results collectively support an organizational framework wherein the forelimb representations contain subzones enriched with neurons tuned for specific actions. Thus, the often-overlooked spatial dimension of neural activity appears to be an important organizing feature of the neural code in frontal motor areas.
影响因子：
5.7
作者：
Friedman RM;Chehade NG;Roe AW;Gharbawie OA
通讯作者：
Gharbawie OA
影响因子：
2.4
作者：
Kaas, Jon H.;Gharbawie, Omar A.;Stepniewska, Iwona
通讯作者：
Stepniewska, Iwona
影响因子：
6.7
作者：
Card, Nicholas S.;Gharbawie, Omar A.
通讯作者：
Gharbawie, Omar A.