Optical imaging reveals functional domains in primate sensorimotor cortex.
Optical imaging reveals functional domains in primate sensorimotor cortex.
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DOI：
10.1016/j.neuroimage.2020.117188
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发表时间：
2020-11-01
期刊：
影响因子：
5.7
通讯作者：
Gharbawie OA
中科院分区：
文献类型：
--
作者：
Friedman RM;Chehade NG;Roe AW;Gharbawie OA
运动皮质(M1)和躯体感觉皮质(S1)是手臂和手控制的中枢。理解M1和S1编码的努力主要集中在神经活动和运动特征之间的时间关系上。然而，目前尚不清楚M1和S1内的神经活动是如何在空间上组织的。光学成像方法非常适合于揭示大脑皮质活动的时空组织，但它们在猴子感觉运动皮质中的应用却很少。在这里，我们研究了本征信号光学成像(ISOI)在测量支持猕猴手臂和手控制的皮质活动方面的有效性。ISOI揭示了M1和S1中活跃的空间域，这些空间域对指令的到达和抓住做出了反应。外侧M1区域与手的表示重叠，并包含一群神经元，在抓握过程中具有最高的放电。相反，内侧M1区域与ARM表示和一群神经元重叠，在REACH过程中放电达到峰值。S1域与区域1和2的手表示以及一组神经元重叠，在与目标的手接触时具有最大的放电。我们的单单位记录表明，ISOI域报告了功能相关神经元的空间簇的位置。因此，ISOI是监测大脑皮层支持运动的“热区”的有效工具。将ISOI的优势与其他成像手段(如功能磁共振成像、双光子成像)和电生理方法相结合，可以在理解运动控制中涉及的皮质信号的时空组织方面开辟新的前沿。
Motor cortex (M1) and somatosensory cortex (S1) are central to arm and hand control. Efforts to understand encoding in M1 and S1 have focused on temporal relationships between neural activity and movement features. However, it remains unclear how the neural activity is spatially organized within M1 and S1. Optical imaging methods are well-suited for revealing the spatio-temporal organization of cortical activity, but their application is sparse in monkey sensorimotor cortex. Here, we investigate the effectiveness of intrinsic signal optical imaging (ISOI) for measuring cortical activity that supports arm and hand control in a macaque monkey. ISOI revealed spatial domains that were active in M1 and S1 in response to instructed reaching and grasping. The lateral M1 domains overlapped the hand representation and contained a population of neurons with peak firing during grasping. In contrast, the medial M1 domain overlapped the arm representation and a population of neurons with peak firing during reaching. The S1 domain overlapped the hand representations of areas 1 and 2 and a population of neurons with peak firing upon hand contact with the target. Our single unit recordings indicate that ISOI domains report the locations of spatial clusters of functionally related neurons. ISOI is therefore an effective tool for surveilling the neocortex for “hot zones” of activity that supports movement. Combining the strengths of ISOI with other imaging modalities (e.g., fMRI, 2-photon) and with electrophysiological methods can open new frontiers in understanding the spatio-temporal organization of cortical signals involved in movement control.
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DOI：
10.1523/jneurosci.1777-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gharbawie OA;Stepniewska I;Qi H;Kaas JH
通讯作者：
Kaas JH
DOI：
10.1073/pnas.88.24.11559
发表时间：
1991-12-01
影响因子：
11.1
作者：
GRINVALD, A;FROSTIG, RD;BARTFELD, E
通讯作者：
BARTFELD, E
影响因子：
64.8
作者：
BLASDEL, GG;SALAMA, G
通讯作者：
SALAMA, G
影响因子：
5.3
作者：
Chen-Bee, Cynthia H.;Agoncillo, Teodora;Frostig, Ron D.
通讯作者：
Frostig, Ron D.
影响因子：
3.7
作者：
Baldwin, Mary K. L.;Cooke, Dylan F.;Krubitzer, Leah
通讯作者：
Krubitzer, Leah