Ionic regulation of cell volume changes and cell death after ischemic stroke.
Ionic regulation of cell volume changes and cell death after ischemic stroke.
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DOI：
10.1007/s12975-013-0314-x
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发表时间：
2014-02
影响因子：
6.9
通讯作者：
Yu, Shan Ping
中科院分区：
文献类型：
--
作者：
Song, Mingke;Yu, Shan Ping
关键词：
中风是美国和世界各地人类死亡和残疾的主要原因。脑缺血后不久，细胞肿胀是受损神经元、胶质细胞和内皮细胞最早的形态学改变。细胞毒性肿胀直接由增加的Na+（与H2O）和Ca 2+通过由膜去极化引起的离子机制流入细胞以及许多有害因素如谷氨酸积累和氧反应性物质（ROS）的产生引起。在缺血后的亚急性和慢性阶段，由于涉及膜受体/通道和程序性细胞死亡信号的复杂过程，受损细胞可能显示出细胞收缩的表型。本文就病理性细胞体积变化的调控机制及其受体和通道的研究进展作一综述，包括NMDA和AMPA受体、酸敏感离子通道（ASIC）、半通道、瞬时受体电位（TRP）通道和KCNQ通道。此外，越来越多的证据支持能量缺乏和Na+/K+-ATP酶功能障碍在缺血诱导的细胞体积变化和细胞死亡中的关键作用。具体而言，Na+泵故障是离子稳态破坏的先决条件，包括K+稳态的促凋亡破坏。最后，我们将介绍作为培养细胞和缺血性脑中Na+泵故障的结果的混合细胞死亡的概念。本文综述了近年来对缺血性细胞毒性离子机制的研究进展，并为今后的转化研究提出了新的思路。
Stroke is a leading cause of human death and disability in the US and around the world. Shortly after the cerebral ischemia, cell swelling is the earliest morphological change in injured neuronal, glial and endothelial cells. Cytotoxic swelling directly results from increased Na+ (with H2O) and Ca2+ influx into cells via ionic mechanisms evoked by membrane depolarization and a number of harmful factors such as glutamate accumulation and the production of oxygen reactive species (ROS). During the sub-acute and chronic phases after ischemia, injured cells may show a phenotype of cell shrinkage due to complex processes involving membrane receptors/channels and programmed cell death signals. This review will introduce some progress in the understanding of the regulation of pathological cell volume changes and the involved receptors and channels, including NMDA and AMPA receptors, acid-sensing ion channels (ASIC), hemichannels, transient receptor potential (TRP) channels and KCNQ channels. Moreover, accumulating evidence supports a key role of energy deficiency and dysfunction of Na+/K+-ATPase in ischemia-induced cell volume changes and cell death. Specifically, the Na+ pump failure is a prerequisite for disruption of ionic homeostasis including a pro-apoptotic disruption of the K+ homeostasis. Finally, we will introduce the concept of hybrid cell death as a result of the Na+ pump failure in cultured cells and the ischemic brain. The goal of this review is to outline recent understanding of the ionic mechanism of ischemic cytoxicity and suggest innovative ideas for future translational research.
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影响因子：
3.7
作者：
Butenko O;Dzamba D;Benesova J;Honsa P;Benfenati V;Rusnakova V;Ferroni S;Anderova M
通讯作者：
Anderova M
影响因子：
5.4
作者：
de Oliveira Otto MC;Nettleton JA;Lemaitre RN;Steffen LM;Kromhout D;Rich SS;Tsai MY;Jacobs DR;Mozaffarian D
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Mozaffarian D
影响因子：
5.3
作者：
Cuomo, Ornella;Gala, Rosaria;Annunziato, Lucio
通讯作者：
Annunziato, Lucio
影响因子：
8.3
作者：
de Pina-Benabou, MH;Szostak, V;Rozental, R
通讯作者：
Rozental, R
DOI：
10.1073/pnas.2233464100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Bruzzone, R;Hormuzdi, SG;Monyer, H
通讯作者：
Monyer, H