Comparative Lipidomic Analyses Reveal Different Protections in Preterm and Term Breast Milk for Infants.
Comparative Lipidomic Analyses Reveal Different Protections in Preterm and Term Breast Milk for Infants.
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比较脂质组学分析揭示了早产儿和足月母乳对婴儿的不同保护作用
DOI：
10.3389/fped.2020.00590
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发表时间：
2020
影响因子：
2.6
通讯作者：
Han S
中科院分区：
文献类型：
--
作者：
Xu L;Chen W;Wang X;Yu Z;Han S
目的：新生儿特别脆弱，但如果喂母乳，他们的结果会有所改善。人乳脂质构成人乳的主要成分，在保护婴儿免受疾病侵害方面起着关键作用。我们评估了早产儿和足月人乳之间的脂质差异，并预测了这些脂质对新生儿发育的前瞻性影响。方法和结果：我们收集了健康的母乳喂养的母亲谁交付无论是足月或早产儿的初乳。我们使用LC-MS/MS代谢组学策略分析了早产儿和足月人乳的脂质谱。正交偏最小二乘判别分析评分图显示早产儿和足月人乳中脂质的显着差异。总共鉴定了235种差异脂质的16个亚类（投影变量重要性> 1，P < 0.05）。值得注意的是，早产儿母乳中磷脂酰乙醇胺和磷脂酰胆碱显著增加，而早产儿母乳中甘油二酯和神经酰胺显著减少。通路分析显示，这些失调的脂质与甘油磷脂代谢、鞘脂代谢、神经元中的Reelin信号传导和LXR/RXR激活密切相关。结论：早产儿和足月儿初乳中的脂质含量不同，这可能对新生儿的发育至关重要。
Aim: Neonates are notably vulnerable, however they have improved outcomes if they are fed human milk. Human milk lipids constitute the primary constituents of human milk and serve a pivotal role in safeguarding infants from diseases. We assessed the lipid differences between preterm and term human milk and predicted the prospective impacts of these lipids on the development of neonates. Methods and results: We collected colostrum from healthy breast-feeding mothers who had delivered either term or preterm infants. We analyzed the lipid profiles of preterm, as well as term human milk using an LC-MS/MS metabolomics strategy. The orthogonal partial least-squares discriminant analysis score plots revealed remarkable distinction of lipids in preterm and term human milk. In total, 16 subclasses of 235 differential lipids (variable importance in projection > 1, P < 0.05) were identified. Notably, phosphatidylethanolamine and phosphatidylcholine were robustly increased in preterm human milk, while diacylglycerol and ceramide were markedly decreased in preterm human milk. Pathway analysis revealed that these dysregulated lipids are closely associated with glycerophospholipid metabolism, sphingolipid metabolism, Reelin signaling in neurons, and LXR/RXR activation. Conclusion: The results show that the lipids in preterm and term human colostrum vary, which may be critical for neonatal development.
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影响因子：
2.6
作者：
Ballard, Olivia;Morrow, Ardythe L.
通讯作者：
Morrow, Ardythe L.
DOI：
10.1038/nrm.2017.107
发表时间：
2018-03
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Hannun YA;Obeid LM
通讯作者：
Obeid LM
影响因子：
2.5
作者：
Corpeleijn, Willemijn E.;Kouwenhoven, Stefanie M. P.;Vermeulen, Marijn J.
通讯作者：
Vermeulen, Marijn J.
影响因子：
3.7
作者：
Britto, Joanne M.;Tait, Karen J.;Tan, Seong-Seng
通讯作者：
Tan, Seong-Seng
影响因子：
7.1
作者：
BITMAN, J;WOOD, DL;HAMOSH, M
通讯作者：
HAMOSH, M