Musculin/MyoR is expressed in kidney side population cells and can regulate their function.
Musculin/MyoR is expressed in kidney side population cells and can regulate their function.
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DOI：
10.1083/jcb.200412167
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发表时间：
2005-06-20
期刊：
影响因子：
--
通讯作者：
Fujita T
中科院分区：
文献类型：
--
作者：
Hishikawa K;Marumo T;Miura S;Nakanishi A;Matsuzaki Y;Shibata K;Ichiyanagi T;Kohike H;Komori T;Takahashi I;Takase O;Imai N;Yoshikawa M;Inowa T;Hayashi M;Nakaki T;Nakauchi H;Okano H;Fujita T
Musculin/MyoR是碱性螺旋-环-螺旋转录因子的新成员，其表达仅限于骨骼肌前体细胞。在此，我们报道 musculin/MyoR 在成人肾侧群 (SP) 细胞中表达，并可以调节其功能。 SP 表型可用于纯化富含干细胞的组分。微阵列分析表明，musculin/MyoR 仅在肾 SP 细胞中表达，并且这些细胞位于肾间质空间中。急性肾衰竭时肌蛋白/MyoR 阳性细胞减少，但输注肾脏 SP 细胞会增加肌蛋白/MyoR 阳性细胞并改善肾功能。可逆性急性肾衰竭中的肾脏SP细胞表达高水平的肾脏保护因子和白血病抑制因子（LIF），但在不可逆性慢性肾衰竭中则不表达。在培养的肾 SP 细胞中，LIF 刺激肾脏保护因子的基因表达，而 musculin/MyoR 的下调增强了 LIF 诱导的基因表达。我们的结果表明，musculin/MyoR 可能不仅在发育过程中发挥重要作用，而且在成体组织的再生过程中也发挥重要作用。
Musculin/MyoR is a new member of basic helix-loop-helix transcription factors, and its expression is limited to skeletal muscle precursors. Here, we report that musculin/MyoR is expressed in adult kidney side population (SP) cells and can regulate their function. SP phenotype can be used to purify stem cell–rich fractions. Microarray analysis clarified that musculin/MyoR was exclusively expressed in kidney SP cells, and the cells resided in the renal interstitial space. Musculin/MyoR-positive cells were decreased in acute renal failure, but infusion of kidney SP cells increased musculin/MyoR-positive cells and improved renal function. Kidney SP cells in reversible acute renal failure expressed a high level of renoprotective factors and leukemia inhibitory factor (LIF), but not in irreversible chronic renal failure. In cultured kidney SP cells, LIF stimulated gene expression of renoprotective factors, and down-regulation of musculin/MyoR augmented LIF-induced gene expression. Our results suggest that musculin/MyoR may play important roles not only in developmental processes but also in regenerative processes in adult tissue.
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影响因子：
7.8
作者：
Asakura, Atsushi;Seale, Patrick;Girgis-Gabardo, Adele;Rudnicki, Michael A
通讯作者：
Rudnicki, Michael A
DOI：
10.1016/j.bbrc.2004.12.167
发表时间：
2005-03-04
影响因子：
3.1
作者：
Hishikawa, K;Marumo, T;Fujita, T
通讯作者：
Fujita, T
影响因子：
2.6
作者：
Robb, L;Hartley, L;Begley, CG
通讯作者：
Begley, CG
影响因子：
13.2
作者：
SURANYI, MG;GUASCH, A;MYERS, BD
通讯作者：
MYERS, BD
影响因子：
15.9
作者：
Ramesh, G;Reeves, WB
通讯作者：
Reeves, WB