Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.
Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.
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DOI：
10.1038/s41380-022-01441-w
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发表时间：
2022-04
影响因子：
11
通讯作者：
Sharp, Gemma
中科院分区：
文献类型：
--
作者：
Caramaschi, Doretta;Neumann, Alexander;Cardenas, Andres;Tindula, Gwen;Alemany, Silvia;Zillich, Lea;Pesce, Giancarlo;Lahti, Jari M. T.;Havdahl, Alexandra;Mulder, Rosa;Felix, Janine F.;Tiemeier, Henning;Sirignano, Lea;Frank, Josef;Witt, Stephanie H.;Rietschel, Marcella;Deuschle, Michael;Huen, Karen;Eskenazi, Brenda;Send, Tabea Sarah;Ferrer, Muriel;Gilles, Maria;de Agostini, Maria;Baiz, Nour;Rifas-Shiman, Sheryl L.;Kvist, Tuomas;Czamara, Darina;Tuominen, Samuli T.;Relton, Caroline L.;Rai, Dheeraj;London, Stephanie J.;Raikkonen, Katri;Holland, Nina;Annesi-Maesano, Isabella;Streit, Fabian;Hivert, Marie-France;Oken, Emily;Sunyer, Jordi;Cecil, Charlotte A. M.;Sharp, Gemma
认知技能是一个强有力的预测广泛的晚年生活的结果。整个基因组的遗传和表观遗传关联解释了一般人群中一般认知能力的一些变化，并且表观遗传关联可能源于产前环境暴露和/或生命早期的遗传变异。我们调查了出生时脐带血DNA甲基化与妊娠和儿童表观遗传学（PACE）联盟内8个妊娠队列儿童的认知技能之间的相关性，包括总体（总N = 2196），言语（总N = 2206）和非言语认知评分（总N = 3300）。在单一的CpG位点的协会是弱的所有的认知领域的调查。在一个调整了母亲智商的模型中，6号染色体上DUSP 22附近的一个区域与非语言认知相关。我们的结论是，几乎没有证据支持脐带血DNA甲基化在单个CpG位点的变化与认知技能相关的观点，需要进一步的研究来证实DUSP 22的相关性。
Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22.
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影响因子：
10.4
作者：
Eskenazi B;Harley K;Bradman A;Weltzien E;Jewell NP;Barr DB;Furlong CE;Holland NT
通讯作者：
Holland NT
DOI：
10.1158/1055-9965.epi-13-1256
发表时间：
2014-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Joubert BR;Håberg SE;Bell DA;Nilsen RM;Vollset SE;Midttun O;Ueland PM;Wu MC;Nystad W;Peddada SD;London SJ
通讯作者：
London SJ
影响因子：
9.8
作者：
Joubert, Bonnie R.;Felix, Janine F.;London, Stephanie J.
通讯作者：
London, Stephanie J.
影响因子：
3.7
作者：
Hannon E;Lunnon K;Schalkwyk L;Mill J
通讯作者：
Mill J
影响因子：
7.7
作者：
Guxens, Monica;Ballester, Ferran;Sunyer, Jordi
通讯作者：
Sunyer, Jordi