Rutin-Loaded Silver Nanoparticles With Antithrombotic Function.
Rutin-Loaded Silver Nanoparticles With Antithrombotic Function.
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DOI：
10.3389/fbioe.2020.598977
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发表时间：
2020
影响因子：
5.7
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Wu H;Su M;Jin H;Li X;Wang P;Chen J;Chen J
在本文中，我们制备了负载芦丁的银纳米粒子（Rutin@AgNPs）作为具有抗血栓功能的纳米抗凝剂。评估了芦丁@AgNPs的血清稳定性、抗凝活性和出血风险。结果表明芦丁@AgNPs具有良好的血清稳定性、血液相容性和细胞相容性。维持了芦丁的抗凝活性，并提高了其稳定性和水溶性。芦丁@AgNPs可以提供持续释放以延长芦丁的半衰期。小鼠模型凝血参数测定和血栓形成试验结果表明，芦丁@AgNPs可延长活化的部分凝血活酶时间和凝血酶原时间，且芦丁@AgNPs在48 h内抑制血栓形成。此外，有限的出血时间表明芦丁@AgNPs显着降低了芦丁的出血风险。这种 Rutin@AgNPs 是一种潜在的抗血栓治疗抗凝剂。
In this paper, we fabricated rutin-loaded silver nanoparticles (Rutin@AgNPs) as the nano-anticoagulant with antithrombotic function. The serum stability, anticoagulation activity, and bleeding risk of Rutin@AgNPs were evaluated. The results showed Rutin@AgNPs had good serum stability, hemocompatibility, and cytocompatibility. The anticoagulation activity of rutin was maintained, and its stability and aqueous solubility were improved. The Rutin@AgNPs could provide a sustained release to prolong the half-life of rutin. The results of the coagulation parameter assay and thrombus formation test in mice model showed that the activated partial thromboplastin time and prothrombin time were prolonged, and Rutin@AgNPs inhibited the thrombosis in the 48 h period. Moreover, the limited bleeding time indicated that the Rutin@AgNPs significantly minimized the hemorrhage risk of rutin. This Rutin@AgNPs is a potential anticoagulant for antithrombotic therapy.
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影响因子：
20.1
作者：
Furie B;Flaumenhaft R
通讯作者：
Flaumenhaft R
DOI：
10.2217/nnm.13.49
发表时间：
2013-06
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Ilinskaya AN;Dobrovolskaia MA
通讯作者：
Dobrovolskaia MA
影响因子：
64.8
作者：
Mackman, Nigel
通讯作者：
Mackman, Nigel
影响因子：
9.3
作者：
Hagimori, Masayori;Kamiya, Seitaro;Arakawa, Masayuki
通讯作者：
Arakawa, Masayuki
影响因子：
5.9
作者：
Piazza, Gregory;Goldhaber, Samuel Z.;Kroll, Aimee;Goldberg, Robert J.;Emery, Catherine;Spencer, Frederick A.
通讯作者：
Spencer, Frederick A.