Prevalence of Parkinson's disease across North America.
Prevalence of Parkinson's disease across North America.
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帕金森氏病的患病率在北美。
DOI：
10.1038/s41531-018-0058-0
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Parkinson’s Foundation P4 Group
中科院分区：
文献类型：
--
作者：
Marras C;Beck JC;Bower JH;Roberts E;Ritz B;Ross GW;Abbott RD;Savica R;Van Den Eeden SK;Willis AW;Tanner CM;Parkinson’s Foundation P4 Group
对北美帕金森病患病率的估计差异很大，许多估计是基于少数病例和小区域亚群。我们试图通过结合来自不同地理区域和/或数据来源的多研究抽样策略的数据来估计帕金森病在北美的患病率。在加州（2）、明尼苏达州（1）、美国夏威夷（1）和加拿大安大略（1）进行的5项独立队列研究根据医疗记录（3）、通过机构、大群体和神经病学实践进行的主动确认（1）以及人群队列的纵向随访（1）估计了PD的患病率。美国医疗保险计划数据提供了相应地区的补充估计。使用我们对加州、明尼苏达和安大略的年龄和性别特异性荟萃估计以及2010年以来的美国人口结构，我们估计年龄≥45岁人群中PD的总体患病率为572/100，000（95%置信区间537-614），2010年美国有680，000例年龄≥45岁的PD患者，2020年该数字将上升至约930，000例，根据美国人口普查局的人口预测，2030年将有238，000人。在项目结果和与之进行比较的基于医疗保险的计算中，也观察到流行率的区域差异。夏威夷研究得出的估计数在各年龄组都较低。这些估计数可以指导保健规划，但应被视为最低估计数。一些异质性仍然存在，有待理解。一项大型研究结合了北美四个不同地区五个不同项目的数据，提供了帕金森病（PD）患病率的最新估计。加拿大多伦多西部医院的Connie Marras及其同事发现，45岁以上人群中，男性的PD患病率高于女性，并且男性和女性的PD患病率均随着年龄的增长而增加。他们估计PD的总患病率为每10万人中有572人，2010年美国有68万人患有PD。随着预期寿命的增加，预计到2030年这一数字将增加到100万以上。作者指出，这些数字应被视为最低患病率估计，警告PD将在不久的将来对北美医疗保健系统产生影响。
Estimates of the prevalence of Parkinson’s disease in North America have varied widely and many estimates are based on small numbers of cases and from small regional subpopulations. We sought to estimate the prevalence of Parkinson’s disease in North America by combining data from a multi-study sampling strategy in diverse geographic regions and/or data sources. Five separate cohort studies in California (2), Minnesota (1), Hawaii USA (1), and Ontario, Canada (1) estimated the prevalence of PD from health-care records (3), active ascertainment through facilities, large group, and neurology practices (1), and longitudinal follow-up of a population cohort (1). US Medicare program data provided complementary estimates for the corresponding regions. Using our age- and sex-specific meta-estimates from California, Minnesota, and Ontario and the US population structure from 2010, we estimate the overall prevalence of PD among those aged ≥45 years to be 572 per 100,000 (95% confidence interval 537–614) that there were 680,000 individuals in the US aged ≥45 years with PD in 2010 and that that number will rise to approximately 930,000 in 2020 and 1,238,000 in 2030 based on the US Census Bureau population projections. Regional variations in prevalence were also observed in both the project results and the Medicare-based calculations with which they were compared. The estimates generated by the Hawaiian study were lower across age categories. These estimates can guide health-care planning but should be considered minimum estimates. Some heterogeneity exists that remains to be understood. A large study that combines data from five different projects in four different regions across North America provides an updated estimate of the prevalence of Parkinson’s disease (PD). Connie Marras at Toronto Western Hospital in Canada and colleagues found that PD prevalence among individuals over 45 years of age is higher among men than women and that it increases with age in both sexes. They estimate that the overall prevalence of PD is 572 per 100,000 and that in the US in 2010 there were 680,000 individuals with PD. As life expectancy increases this number is projected to increase to over one million by 2030. These figures, which the authors note should be considered minimum prevalence estimates, warn of the impact that PD will have on North America’s healthcare systems in the near future.
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影响因子：
9.9
作者：
Bower, JH;Maraganore, DM;Rocca, WA
通讯作者：
Rocca, WA
影响因子：
9.9
作者：
SCHOENBERG, BS;ANDERSON, DW;HAERER, AF
通讯作者：
HAERER, AF
影响因子：
5.7
作者：
Willis, Allison Wright;Evanoff, Bradley A.;Racette, Brad A.
通讯作者：
Racette, Brad A.
影响因子：
--
作者：
SCHOENBERG, BS;ANDERSON, DW;HAERER, AF
通讯作者：
HAERER, AF
影响因子：
8.6
作者：
Gordon, Paul H.;Mehal, Jason M.;Cheek, James E.
通讯作者：
Cheek, James E.