Brain structure in autism: a voxel-based morphometry analysis of the Autism Brain Imaging Database Exchange (ABIDE).
Brain structure in autism: a voxel-based morphometry analysis of the Autism Brain Imaging Database Exchange (ABIDE).
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DOI：
10.1007/s11682-016-9534-5
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发表时间：
2017-04
影响因子：
3.2
通讯作者：
Woodward, Neil D.
中科院分区：
文献类型：
--
作者：
Riddle, Kaitlin;Cascio, Carissa J.;Woodward, Neil D.
脑容量增加是自闭症谱系障碍（ASD）幼儿的一致发现;然而，异常脑结构的区域特异性和发育过程尚不清楚。小样本量，特别是在基于体素的形态测量（VBM）的调查，可能会导致这种困难。最近建立的大规模神经影像学数据库有助于澄清神经精神疾病，如精神分裂症的神经解剖学，并可能被证明是有用的ASD。来自自闭症脑成像数据库交换（ABIDE）的结构脑图像，包含1100多名参与者，使用DARTEL VBM进行分析，以研究ASD的总脑和组织体积以及局部脑结构异常。分析了两个重叠的队列;一个是“所有受试者”队列（n=833），包括所有具有可用MRI数据的个体，另一个是“匹配样本”队列（n=600），包括每个研究中心内年龄和性别匹配的ASD和TD个体。ASD患者的总脑和灰质体积增大约1-2%;然而，仅所有受试者队列的影响达到统计学显著性。在所有受试者队列中，VBM分析显示ASD患者左前上级颞回增大。在匹配样本队列中未检测到显著的区域变化。与TD相比，ASD中IQ和TBV之间的相关性没有显著降低。6岁及以上ASD患者的脑结构异常包括由于灰质增大而导致的总脑体积的微妙增加，几乎没有区域特异性影响的证据。
Increased brain volume is a consistent finding in young children with autism spectrum disorders (ASD); however, the regional specificity and developmental course of abnormal brain structure are less clear. Small sample sizes, particularly among voxel-based morphometry (VBM) investigations, likely contribute to this difficulty. Recently established large-scale neuroimaging data repositories have helped clarify the neuroanatomy of neuropsychiatric disorders such as schizophrenia and may prove useful in ASD. Structural brain images from the Autism Brain Imaging Database Exchange (ABIDE), which contains over 1100 participants, were analyzing using DARTEL VBM to investigate total brain and tissue volumes, and regional brain structure abnormalities in ASD. Two, overlapping cohorts were analyzed; an ‘All Subjects’ cohort (n=833) that included all individuals with usable MRI data, and a ‘Matched Samples’ cohort (n=600) comprised of ASD and TD individuals matched, within each site, on age and sex. Total brain and grey matter volumes were enlarged by approximately 1–2% in ASD; however, the effect reached statistical significance on only the All Subjects cohort. Within the All Subjects cohort, VBM analysis revealed enlargement of the left anterior superior temporal gyrus in ASD. No significant regional changes were detected in the Matched Samples cohort. There was a non-significant reduction in the correlation between IQ and TBV in ASD compared to TD. Brain structure abnormalities in ASD individuals age 6 and older consists of a subtle increase in total brain volume due to enlargement of grey matter with little evidence of regionally specific effects.
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影响因子：
4.7
作者：
Duerden, Emma G.;Mak-Fan, Kathleen M.;Roberts, S. Wendy
通讯作者：
Roberts, S. Wendy
DOI：
10.1016/j.nicl.2014.11.004
发表时间：
2015
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
DeRamus TP;Kana RK
通讯作者：
Kana RK
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.
影响因子：
9.9
作者：
Aylward, EH;Minshew, NJ;Singh, N
通讯作者：
Singh, N
DOI：
10.1097/00004583-200109000-00009
发表时间：
2001-09-01
影响因子：
13.3
作者：
Durston, S;Pol, HEH;van Engeland, H
通讯作者：
van Engeland, H