The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population.
The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population.
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中国人群人类白细胞抗原DP/DQ基因多态性与HCV感染结局的关系
DOI：
10.1186/s12985-017-0901-7
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发表时间：
2017-12-06
期刊：
影响因子：
4.8
通讯作者：
Yue M
中科院分区：
文献类型：
--
作者：
Huang P;Fan H;Tian T;Liao P;Li J;Yu R;Xia X;Feng Y;Wang J;Liu Y;Zhang Y;Yue M
近年来，人类白细胞抗原（HLA）Ⅱ类基因多态性与丙型肝炎病毒（HCV）感染及慢性化有关。本研究旨在探讨HLA-DP rs 9277535和HLA-DQ rs7453920与HCV感染预后的关系。采用ABI TaqMan等位基因识别试验对370例慢性HCV感染者、194例HCV自发清除者和973例非HCV感染者进行rs 9277535和rs7453920基因分型。Logistic回归分析显示，rs7453920的次要等位基因A在显性模型（校正OR = 1.33，95%CI：1.04-1.71，P = 0.026）和加性模型（校正OR = 1.30，95%CI：1.06-1.60，P = 0.012）中均显著增加HCV感染的易感性。在显性模型中，Rs 9277535 A等位基因显著增加慢性HCV感染的风险（校正OR = 1.52，95% CI：1.01-2.28，P = 0.046）。单倍型AA比最常见的单倍型GG感染HCV的风险更高（校正OR = 1.37，95%CI：1.05-1.78，P = 0.018）。HLA-DQ rs7453920和-DP rs 9277535突变分别与HCV感染易感性和慢性化显著相关。本文的在线版本（10.1186/s12985-017-0901-7）包含补充材料，可供授权用户使用。
Recently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationship of HLA-DP rs9277535 and HLA-DQ rs7453920 with the outcomes of HCV infection. The rs9277535 and rs7453920 were genotyped in 370 subjects with chronic HCV infection, 194 subjects with spontaneous HCV clearance, and 973 subjects with non-HCV infection from the Chinese population using the ABI TaqMan allelic discrimination assay. Logistic regression analyses showed that the minor allele A of rs7453920 significantly increased the susceptibility of HCV infection in dominant model (adjusted OR = 1.33, 95% CI: 1.04–1.71, P = 0.026) and additive models (adjusted OR = 1.30, 95% CI: 1.06–1.60, P = 0.012). Rs9277535 A allele significantly increased the risk of chronic HCV infection in dominant model (adjusted OR = 1.52, 95% CI: 1.01–2.28, P = 0.046). Haplotype AA showed a higher risk of HCV infection than the most frequent haplotype GG (adjusted OR = 1.37, 95% CI: 1.05–1.78, P = 0.018). The HLA-DQ rs7453920 and -DP rs9277535 mutations were significantly associated with HCV infection susceptibility and chronicity, respectively. The online version of this article (10.1186/s12985-017-0901-7) contains supplementary material, which is available to authorized users.
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