Genetics of ascites resistance and tolerance in chicken: a random regression approach.
Genetics of ascites resistance and tolerance in chicken: a random regression approach.
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DOI：
10.1534/g3.112.002311
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Bovenhuis H
中科院分区：
文献类型：
--
作者：
Kause A;van Dalen S;Bovenhuis H
抗性和耐受性是两种互补的机制，以减少寄生虫，病原体和生产疾病对宿主性能的不利影响。使用体重和腹水数据的驯化鸡原鸡，我们展示了使用随机回归动物模型和协方差函数估计遗传参数的腹水抗性和耐受性，并说明了如何在抗性和耐受性的个体变异诱导基因型重新排序和主机性能的变化沿着增加腹水的严重程度。耐腹水性表现出显着的遗传变异，与估计的育种值的耐受性斜率范围从强负（非常敏感的基因型）到弱负（不太敏感）。抗腹水的遗传力为0.34。因此，这两种性状都被认为对选择有反应。两种互补的防御策略，耐受性和抗性，在遗传上是独立的。腹水引起腹水抵抗力和体重之间的相关性的变化，与遗传相关性弱时，鸟类无腹水，但中度负健康和受影响的鸟类时，本。这可能是因为腹水减少生长，因此腹水发生率高与成人体重低有遗传关系。尽管腹水会导致受影响鸟类体重的表型和遗传变异增加，但健康鸟类和受影响鸟类的遗传力变化可以忽略不计。腹水诱导中度基因型重新排名体重，与健康的鸟类与轻度受影响的鸟类的遗传相关性是统一的，但与严重受影响的鸟类0.45。这项研究为探索防御性状的遗传学及其对基因型与环境相互作用的影响提供了一种新的方法。
Resistance and tolerance are two complementary mechanisms to reduce the detrimental effects of parasites, pathogens, and production diseases on host performance. Using body weight and ascites data on domesticated chicken Gallus gallus domesticus, we demonstrate the use of random regression animal model and covariance functions to estimate genetic parameters for ascites resistance and tolerance and illustrate the way individual variation in resistance and tolerance induce both genotype re-ranking and changes in variation of host performance along increasing ascites severity. Tolerance to ascites displayed significant genetic variance, with the estimated breeding values of tolerance slope ranging from strongly negative (very sensitive genotype) to weakly negative (less sensitive). Resistance to ascites had heritability of 0.34. Both traits are hence expected to respond to selection. The two complementary defense strategies, tolerance and resistance, were genetically independent. Ascites induced changes to the correlations between ascites resistance and body weight, with the genetic correlations being weak when birds were ascites-free but moderately negative when both healthy and affected birds were present. This likely results because ascites reduces growth, and thus high ascites incidence is genetically related to low adult body weight. Although ascites induced elevated phenotypic and genetic variances in body weight of affected birds, heritability displayed negligible changes across healthy and affected birds. Ascites induced moderate genotype re-ranking in body weight, with the genetic correlation of healthy birds with mildly affected birds being unity but with severely affected birds 0.45. This study demonstrates a novel approach for exploring genetics of defense traits and their impact on genotype-by-environment interactions.
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影响因子：
64.8
作者：
FINEBLUM, WL;RAUSHER, MD
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2
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作者：
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