The role of ghrelin in reward-based eating.

The role of ghrelin in reward-based eating.
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DOI:
10.1016/j.biopsych.2012.02.016
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发表时间:
2012-09-01
影响因子:
10.6
通讯作者:
Zigman, Jeffrey M.
Zigman, Jeffrey M.
中科院分区:
医学1区
文献类型:
--
作者:
Perello, Mario;Zigman, Jeffrey M.

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The peptide hormone ghrelin acts in the central nervous system as a potent orexigenic signal. Not only is ghrelin recognized as playing an important role in feeding circuits traditionally thought of as affecting body weight homeostasis, but an accumulating number of scientific studies now have identified ghrelin as being a key regulator of reward-based, hedonic eating behaviors. In the current article, we review ghrelin’s orexigenic actions, the evidence linking ghrelin to food reward behavior, potential mechanisms by which ghrelin mediates reward-based eating behavior, and those studies suggesting an obligatory role for ghrelin in the changed eating behaviors induced by stress.
具有设计的生长素蛋白O-酰基转移酶抑制剂的小鼠中的葡萄糖和体重控制。
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