Causal effects of fatty acids on atopic dermatitis: A Mendelian randomization study.
Causal effects of fatty acids on atopic dermatitis: A Mendelian randomization study.
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脂肪酸对特应性皮炎的因果影响：孟德尔随机研究。
DOI：
10.3389/fnut.2023.1083455
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发表时间：
2023
影响因子：
5
通讯作者：
Bai, Bing-Xue
中科院分区：
文献类型：
--
作者：
Lin, Jia-Ying;Ma, Liang-Juan;Yuan, Jin-Ping;Yu, Pei;Bai, Bing-Xue
一些证据表明特应性皮炎（AD）患者的脂肪酸异常，并且已经报道了补充这些脂肪酸的益处。然而，脂肪酸与AD的相关性仍存在很大争议。因此，本研究的目的是使用孟德尔随机化方法确定脂肪酸水平是否与AD有因果关系。我们用全基因组关联研究（GWAS）的各种方法评估了脂肪酸水平与AD的相关数据。GWAS结果可从欧洲血统获得。采用孟德尔随机化方法分析脂肪酸对AD的因果关系。采用MR Egger和MR-ESTO确定多效性和异质性。使用与FADS基因相关的仪器进行进一步分析，以解决所涉及的机制。我们还使用多变量MR（MVMR）来显示omega-3（n-3）脂肪酸对AD的独立因果推断。孟德尔随机化（MR）分析表明，n-3脂肪酸水平与AD风险降低相关（n-3 ORIVW：0.92，95%置信区间[CI]：0.87-0.98; p = 0.01）。此外，二十二碳六烯酸（DHA）是一种长链、高度不饱和的ω-3（n-3）脂肪酸，其水平较高与AD风险较低相关（DHA ORIVW：0.91，95% CI：0.84-0.98; p = 0.02）。我们进行多变量MR分析，同时控制其他类型脂肪酸内的变量。效应估计值与初步MR分析一致，表明n-3脂肪酸水平对AD的影响是稳健的。MR-egger提示遗传工具变异无明显的多效性和异质性。控制水平多效性后，离群值校正的MR分析仍然稳健。单SNP分析显示，n-3脂肪酸可能通过FADS簇与AD风险降低相关，突出了脂肪酸合成途径中FADS基因在AD发展中的重要性。我们的研究表明，n-3脂肪酸可以降低AD的风险。基于n-3脂肪酸水平的风险预测工具可能是改善AD筛查和一级预防的有价值的方法。为了降低AD的风险，个人可以通过补充或饮食来增加n-3脂肪酸的摄入。
Some evidence suggests abnormalities in fatty acids in patients with atopic dermatitis (AD), and benefits of supplementation with these fatty acids have been reported. However, there is still substantial controversy on the correlation between fatty acids and AD. Therefore, the aim of this study was to determine whether fatty acid levels are causally related to AD using a Mendelian randomization approach. We evaluated the data about the fatty acids levels and AD with various methods from Genome-Wide Association Study (GWAS). GWAS results were available both from European ancestry. Mendelian randomization methods were used to analysis the casual inference of fatty acids on AD. MR Egger and MR-PRESSO were used to determine pleiotropy and heterogeneity. Further analysis was conducted using instruments associated with the FADS genes to address mechanisms involved. We also used Multivariate MR (MVMR) to show the independent casual inference of omega-3 (n-3) fatty acids on AD. Mendelian randomization (MR) analysis suggests that n-3 fatty acid levels are associated with a lower risk of AD (n-3 ORIVW: 0.92, 95% confidence interval [CI]: 0.87–0.98; p = 0.01). Moreover, docosahexaenoic acids (DHA) levels, which is a kind of long-chain, highly unsaturated omega-3 (n-3) fatty acid, and its higher level was associated with a lower risk of AD (DHA ORIVW: 0.91, 95% CI: 0.84–0.98; p = 0.02). We ran multivariable MR analysis while controlling for variables within the other types of fatty acids. The effect estimates agreed with the preliminary MR analysis indicating the effect of n-3 fatty acids levels on AD was robust. MR-egger suggest no significant pleiotropy and heterogeneity on genetic instrumental variants. Outliers-corrected MR analyses after controlling horizontal pleiotropy were still robust. The single-SNP analyses revealed that n-3 fatty acids are likely linked to a decreased risk of AD through FADS cluster, highlighting the significance of the FADS gene in the fatty acids synthesis pathway in the development of AD. Our studies suggest that n-3 fatty acids may reduce the risk of AD. Risk prediction tools based on n-3 fatty acid levels may be valuable methods for improving AD screening and primary prevention. To reduce the risk of AD, individuals could enhance n-3 fatty acids intake through supplement or diet.
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影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
影响因子：
6.1
作者：
Linnamaa, P.;Savolainen, J.;Tahvonen, R.
通讯作者：
Tahvonen, R.
影响因子：
24
作者：
Lazaro, Iolanda;Lupon, Josep;Bayes-Genis, Antoni
通讯作者：
Bayes-Genis, Antoni
影响因子：
3.6
作者：
Fujii, Masanori;Nakashima, Hiroyuki;Nabe, Takeshi
通讯作者：
Nabe, Takeshi
影响因子：
7.1
作者：
Horrobin, DF
通讯作者：
Horrobin, DF