The effect of high intensity focused ultrasound treatment on metastases in a murine melanoma model.
The effect of high intensity focused ultrasound treatment on metastases in a murine melanoma model.
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DOI：
10.1016/j.bbrc.2008.08.072
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发表时间：
2008-10-31
影响因子：
3.1
通讯作者：
Zhong, Pei
中科院分区：
文献类型：
--
作者：
Xing, Yifei;Lu, Xiaochun;Pua, Eric C.;Zhong, Pei
本研究旨在评估高强度聚焦超声（HIFU）治疗对远处转移发生率的风险，并在小鼠黑色素瘤（B16-F10）模型中研究其与HIFU诱导的抗肿瘤免疫的相关性。在HIFU治疗后立即或2天后截肢，以区分引发的抗肿瘤免疫的贡献。在接受机械、热或无HIFU治疗后立即截肢的小鼠中，转移率相当（18.8%、13.3%和12.5%）。相比之下，延迟2天截肢，相应的转移率分别为6.7%，11.8%和40%。HIFU治疗组动物存活率较高，CTL活性增强。总之，我们的研究结果表明，HIFU治疗不会增加远处转移的风险。相反，HIFU治疗可以引发抗肿瘤免疫反应，可以利用这种免疫反应来提高癌症治疗的整体有效性和质量。
This study aims to assess the risk of high intensity focused ultrasound (HIFU) therapy on the incidence of distant metastases and to investigate its association with HIFU-elicited anti-tumor immunity in a murine melanoma (B16-F10) model. Tumor-bearing legs were amputated immediately after or 2 days following HIFU treatment to differentiate the contribution of the elicited anti-tumor immunity. In mice undergoing amputation immediately after mechanical, thermal, or no HIFU treatment, metastasis rates were comparable (18.8%, 13.3% and 12.5 %). In contrast, with a 2-day delay in amputation, the corresponding metastasis rates were 6.7%, 11.8% and 40%, respectively. Animal survival rate was higher and CTL activity was enhanced in the HIFU treatment groups. Altogether, our results suggest that HIFU treatment does not increase the risk of distant metastasis. Instead, HIFU treatment can elicit an anti-tumor immune response that may be harnessed to improve the overall effectiveness and quality of cancer therapy.
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DOI：
10.1038/newbio242148a0
发表时间：
1973-01-01
期刊：
NATURE-NEW BIOLOGY
影响因子：
--
作者：
FIDLER, IJ
通讯作者：
FIDLER, IJ
转移的临床模式
影响因子：
9.2
作者：
Leong, Stanley P. L.;Cady, Blake;Kitajima, M.
通讯作者：
Kitajima, M.
影响因子：
82.9
作者：
Contag, PR;Olomu, IN;Contag, CH
通讯作者：
Contag, CH
影响因子：
4.8
作者：
Rehemtulla, A;Stegman, LD;Ross, BD
通讯作者：
Ross, BD
影响因子：
8.8
作者：
Wu, F;Wang, Z-B;Cao, Y-De;Chen, W-Z;Bai, J;Zou, J-Z;Zhu, H
通讯作者：
Zhu, H