What targeting eosinophils has taught us about their role in diseases.
What targeting eosinophils has taught us about their role in diseases.
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DOI：
10.1016/j.jaci.2010.02.026
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Gleich GJ
中科院分区：
文献类型：
--
作者：
Bochner BS;Gleich GJ
嗜酸性粒细胞相关疾病是一个术语，用于涵盖从嗜酸性粒细胞增多综合征到哮喘等一系列疾病。尽管长期以来人们认为嗜酸性粒细胞可能是疾病病理生理学的主要促成因素，但直到近年来才能够在动物或人类中实现对嗜酸性粒细胞的直接和选择性减少或消除。通过巧妙地针对嗜酸性粒细胞的产生，在小鼠中实现了这些进展。使用针对可溶性嗜酸性粒细胞相关分子（如白细胞介素 - 5（IL - 5））或细胞表面结构（如CCR3）的抗体和其他药物，也已证明在减少血液和组织中的嗜酸性粒细胞方面是有用的。在人类中，到目前为止在临床试验中测试的唯一的嗜酸性粒细胞选择性药物是针对IL - 5的中和抗体，结果有希望但喜忧参半。至少，这种对嗜酸性粒细胞在某些气道、胃肠道和血液疾病中作用的药理学假设检验形式，最终为我们提供了对疾病发病机制的新见解。从最乐观的角度来看，这些和其他靶向药物也许有一天可用于患有嗜酸性粒细胞相关疾病的患者。这篇综述总结了在嗜酸性粒细胞导向疗法的临床前和临床研究中体内所了解到的情况，重点是近期的进展。
Eosinophil-associated disease is a term used to encompass a range of disorders from hypereosinophilic syndrome to asthma. Despite the longstanding belief that eosinophils can be primary contributors to disease pathophysiology, it is only in recent years that direct and selective reduction or elimination of eosinophils can be achieved in animals or in humans. These developments have been made possible in mice through clever targeting of eosinophil production. Use of antibodies and other agents that target soluble eosinophil-related molecules such as interleukin-5 (IL-5) or cell surface structures such as CCR3 has also proved useful in reducing blood and tissue eosinophils. In humans, the only eosinophil-selective agents tested in clinical trials so far are neutralizing antibodies to IL-5, with promising but mixed results. At the very least, such forms of pharmacologic hypothesis testing of the role of eosinophils in certain airway, gastrointestinal and hematologic diseases has finally provided us with new insights into disease pathogenesis. At its optimistic best, these and other targeted agents may someday become available for those afflicted with eosinophil-associated disorders. This review summarizes what has been learned in vivo in both preclinical and clinical studies of eosinophil-directed therapies, with an emphasis on recent advances.
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白介素5缺乏消除小鼠哮喘模型中的嗜酸性粒细胞，气道高反应性和肺损伤。
影响因子：
15.3
作者：
Foster, PS;Hogan, SP;Ramsay, AJ;Matthaei, KI;Young, IG
通讯作者：
Young, IG
DOI：
10.1164/ajrccm/138.3.685
发表时间：
1988-09-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
FLAVAHAN, NA;SLIFMAN, NR;VANHOUTTE, PM
通讯作者：
VANHOUTTE, PM
影响因子：
4.4
作者：
Forbes, E;Murase, T;Hogan, SP
通讯作者：
Hogan, SP
DOI：
10.1084/jem.172.5.1425
发表时间：
1990-11-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dent LA;Strath M;Mellor AL;Sanderson CJ
通讯作者：
Sanderson CJ
DOI：
10.1073/pnas.84.19.6629
发表时间：
1987-10-01
影响因子：
11.1
作者：
CAMPBELL, HD;TUCKER, WQJ;YOUNG, IG
通讯作者：
YOUNG, IG