Surrogate markers of visceral adiposity in young adults: waist circumference and body mass index are more accurate than waist hip ratio, model of adipose distribution and visceral adiposity index.
Surrogate markers of visceral adiposity in young adults: waist circumference and body mass index are more accurate than waist hip ratio, model of adipose distribution and visceral adiposity index.
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DOI：
10.1371/journal.pone.0114112
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Escobar-Morreale HF
中科院分区：
文献类型：
--
作者：
Borruel S;Moltó JF;Alpañés M;Fernández-Durán E;Álvarez-Blasco F;Luque-Ramírez M;Escobar-Morreale HF
内脏肥胖的替代指标是代谢和心血管疾病的主要危险因素，在临床实践中常规使用，因为内脏肥胖的客观测量价格昂贵，可能涉及辐射暴露，并且其可用性有限。我们比较了 99 名年轻白人成年人（包括 20 名无雄激素过多的女性、53 名患有多囊卵巢综合征的女性和 26 名男性）的皮下和内脏脂肪组织储库的超声评估的内脏肥胖替代指标。分别有 7 名、21 名和 7 名受试者存在肥胖。我们获得了体重指数（BMI）、腰围（WC）、腰臀比（WHR）、脂肪分布模型（MOAD）、内脏肥胖指数（VAI）以及皮下和内脏脂肪组织库和肝脏脂肪变性的超声测量结果。 WC 和 BMI 与内脏肥胖的超声测量结果显示出最强的相关性。只有腰臀比与性激素相关。包括VAI在内的线性逐步回归模型在解释胰岛素敏感性指数变异性方面仅略强于包括BMI或WC的模型（但BMI和WC具有更高的个体标准化回归系数），并且这些模型优于包括WHR和MOAD的模型。根据受试者工作特征曲线分析，WC 显示出 0.94（95% 置信区间 0.88-0.99），BMI 显示出 0.91（0.85-0.98）的概率来识别肝脂肪变性的存在。总之，WC和BMI不仅是最容易获得的，而且是年轻人内脏肥胖最准确的替代标志物，是胰岛素抵抗的良好指标和肝脂肪变性的有力预测因子。
Surrogate indexes of visceral adiposity, a major risk factor for metabolic and cardiovascular disorders, are routinely used in clinical practice because objective measurements of visceral adiposity are expensive, may involve exposure to radiation, and their availability is limited. We compared several surrogate indexes of visceral adiposity with ultrasound assessment of subcutaneous and visceral adipose tissue depots in 99 young Caucasian adults, including 20 women without androgen excess, 53 women with polycystic ovary syndrome, and 26 men. Obesity was present in 7, 21, and 7 subjects, respectively. We obtained body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), model of adipose distribution (MOAD), visceral adiposity index (VAI), and ultrasound measurements of subcutaneous and visceral adipose tissue depots and hepatic steatosis. WC and BMI showed the strongest correlations with ultrasound measurements of visceral adiposity. Only WHR correlated with sex hormones. Linear stepwise regression models including VAI were only slightly stronger than models including BMI or WC in explaining the variability in the insulin sensitivity index (yet BMI and WC had higher individual standardized coefficients of regression), and these models were superior to those including WHR and MOAD. WC showed 0.94 (95% confidence interval 0.88–0.99) and BMI showed 0.91 (0.85–0.98) probability of identifying the presence of hepatic steatosis according to receiver operating characteristic curve analysis. In conclusion, WC and BMI not only the simplest to obtain, but are also the most accurate surrogate markers of visceral adiposity in young adults, and are good indicators of insulin resistance and powerful predictors of the presence of hepatic steatosis.
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影响因子：
5.8
作者：
Borruel, Susana;Fernandez-Duran, Elena;Escobar-Morreale, Hector F.
通讯作者：
Escobar-Morreale, Hector F.
影响因子：
6.7
作者：
Escobar-Morreale, HF;Lasunción, MA;Sancho, J
通讯作者：
Sancho, J
DOI：
10.2165/00129784-200404040-00004
发表时间：
2004-01-01
期刊：
American journal of cardiovascular drugs : drugs, devices, and other interventions
影响因子：
--
作者：
Chan, Dick C;Barrett, Hugh P R;Watts, Gerald F
通讯作者：
Watts, Gerald F
影响因子：
6.1
作者：
Fauser, BCJM;Chang, J;Lobo, R
通讯作者：
Lobo, R
影响因子：
1.6
作者：
Ferrannini, Ele;Sironi, Anna Maria;Gastaldelli, Amalia
通讯作者：
Gastaldelli, Amalia