Ancient DNA reveals genetic connections between early Di-Qiang and Han Chinese.
Ancient DNA reveals genetic connections between early Di-Qiang and Han Chinese.
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古代DNA揭示了早期氐羌族与汉族之间的遗传联系
DOI：
10.1186/s12862-017-1082-0
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发表时间：
2017-12-04
影响因子：
3.4
通讯作者：
Zhou H
中科院分区：
文献类型：
--
作者：
Li J;Zeng W;Zhang Y;Ko AM;Li C;Zhu H;Fu Q;Zhou H
古狄羌人曾经居住在中国的甘庆地区，毗邻汉族的起源地中原地区。虽然有人提出了羌族和汉族之间的基因流动，但没有证据支持这一观点。在这里，我们分析了早期地羌遗址（距今约4000年）的人类遗骸，并将其与中国其他古代DNA进行了比较，包括早期汉遗址（距今约3000年），以建立地羌与汉人祖先之间的潜在遗传关系。结果表明，摩狗的mtDNA单倍群多样性较高，包括A、B、C、D （D*、D4、D5）、F、G、M7、M8、M10、M13、M25、N*、N9a、z等14个单倍群，而摩狗雄性均为Y-DNA单倍群O3a2/P201；具体来说，利用y染色体非重组区域的靶向独特区域，进一步将一名男性分配到O3a2c1a/M117上。通过与中国其他7个古代群体和38个现代群体（1793个个体）的比较，发现莫沟人与陶家寨人（近代迪羌人）、衡北人和北汉人具有相近的遗传距离。我们使用近似贝叶斯计算模拟了它们之间的相互作用，并支持了在3300-3800年前，摩沟和北汉之间可能有13-18%的混合。漠沟拥有最早的可遗传鉴定的地羌人，其祖先为陶家寨人，在现代北方汉族中可发现高达33%的父系单倍群和70%的母系单倍群。本文的在线版本（10.1186/s12862-017-1082-0）包含补充材料，仅供授权用户使用。
Ancient Di-Qiang people once resided in the Ganqing region of China, adjacent to the Central Plain area from where Han Chinese originated. While gene flow between the Di-Qiang and Han Chinese has been proposed, there is no evidence to support this view. Here we analyzed the human remains from an early Di-Qiang site (Mogou site dated ~4000 years old) and compared them to other ancient DNA across China, including an early Han-related site (Hengbei site dated ~3000 years old) to establish the underlying genetic relationship between the Di-Qiang and ancestors of Han Chinese. We found Mogou mtDNA haplogroups were highly diverse, comprising 14 haplogroups: A, B, C, D (D*, D4, D5), F, G, M7, M8, M10, M13, M25, N*, N9a, and Z. In contrast, Mogou males were all Y-DNA haplogroup O3a2/P201; specifically one male was further assigned to O3a2c1a/M117 using targeted unique regions on the non-recombining region of the Y-chromosome. We compared Mogou to 7 other ancient and 38 modern Chinese groups, in a total of 1793 individuals, and found that Mogou shared close genetic distances with Taojiazhai (a more recent Di-Qiang population), Hengbei, and Northern Han. We modeled their interactions using Approximate Bayesian Computation, and support was given to a potential admixture of ~13-18% between the Mogou and Northern Han around 3300–3800 years ago. Mogou harbors the earliest genetically identifiable Di-Qiang, ancestral to the Taojiazhai, and up to ~33% paternal and ~70% of its maternal haplogroups could be found in present-day Northern Han Chinese. The online version of this article (10.1186/s12862-017-1082-0) contains supplementary material, which is available to authorized users.
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影响因子：
4.5
作者：
Der Sarkissian C;Balanovsky O;Brandt G;Khartanovich V;Buzhilova A;Koshel S;Zaporozhchenko V;Gronenborn D;Moiseyev V;Kolpakov E;Shumkin V;Alt KW;Balanovska E;Cooper A;Haak W;Genographic Consortium
通讯作者：
Genographic Consortium
影响因子：
--
作者：
HUMMEL, S;HERRMANN, B
通讯作者：
HERRMANN, B
影响因子：
5.3
作者：
Kong, QP;Yao, YG;Zhang, YP
通讯作者：
Zhang, YP
DOI：
10.1186/2041-2223-5-13
发表时间：
2014
期刊：
Investigative genetics
影响因子：
--
作者：
Lippold S;Xu H;Ko A;Li M;Renaud G;Butthof A;Schröder R;Stoneking M
通讯作者：
Stoneking M
影响因子：
2.9
作者：
Jurado Medina, Laura Smeldy;Muzzio, Marina;Bailliet, Graciela
通讯作者：
Bailliet, Graciela