Metabolic actions of kisspeptin signaling: Effects on body weight, energy expenditure, and feeding.
Metabolic actions of kisspeptin signaling: Effects on body weight, energy expenditure, and feeding.
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DOI：
10.1016/j.pharmthera.2021.107974
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发表时间：
2022-03
影响因子：
13.5
通讯作者：
Kauffman AS
中科院分区：
文献类型：
--
作者：
Hudson AD;Kauffman AS
Kisspeptin(由Kiss1基因编码)及其受体KISS1R(由Kiss1r基因编码)通过对生殖神经回路的中枢作用来刺激生殖，但最近的证据表明Kisspeptin信号也影响新陈代谢和能量平衡。事实上，Kiss1和Kiss1r在许多与代谢相关的外周组织中都有表达，包括白色和棕色脂肪组织、肝脏和胰腺，这表明可能对这些组织采取行动或参与其生理活动。此外，还可能存在kisspeptin信号的中枢作用，或kisspeptin神经元共同释放的调节代谢、摄食或体温调节过程的因子。从动物模型中积累的数据表明，Kispeptin信号调节广泛的代谢参数，包括体重和能量消耗、脂肪和脂肪组织功能、食物摄入量、葡萄糖代谢、呼吸频率、运动活动和体温调节。在此，我们回顾了Kispeptin信号参与这些生理参数的现有证据，指出了知识上的差距，并强调了未来重要研究的途径。总而言之，这些讨论的结果强调了Kispeptin信号在新陈代谢和能量平衡中新出现的非生殖作用，以及先前已证实的在生殖控制中的作用，但也强调了需要更多的研究来解决当前的争议，并揭示潜在的分子和生理机制。
Kisspeptin (encoded by the Kiss1 gene) and its receptor, KISS1R (encoded by the Kiss1r gene), have well-established roles in stimulating reproduction via central actions on reproductive neural circuits, but recent evidence suggests that kisspeptin signaling also influences metabolism and energy balance. Indeed, both Kiss1 and Kiss1r are expressed in many metabolically-relevant peripheral tissues, including both white and brown adipose tissue, the liver, and the pancreas, suggesting possible actions on these tissues or involvement in their physiology. In addition, there may be central actions of kisspeptin signaling, or factors co-released from kisspeptin neurons, that modulate metabolic, feeding, or thermoregulatory processes. Accumulating data from animal models suggests that kisspeptin signaling regulates a wide variety of metabolic parameters, including body weight and energy expenditure, adiposity and adipose tissue function, food intake, glucose metabolism, respiratory rates, locomotor activity, and thermoregulation. Herein, the current evidence for the involvement of kisspeptin signaling in each of these physiological parameters is reviewed, gaps in knowledge identified, and future avenues of important research highlighted. Collectively, the discussed findings highlight emerging non-reproductive actions of kisspeptin signaling in metabolism and energy balance, in addition to previously documented roles in reproductive control, but also emphasize the need for more research to resolve current controversies and uncover underlying molecular and physiological mechanisms.
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影响因子：
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作者：
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通讯作者：
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DOI：
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