Protein-mediated enamel mineralization.

Protein-mediated enamel mineralization.
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DOI:
10.2741/4034
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发表时间:
2012-06-01
期刊:
Frontiers in bioscience (Landmark edition)
影响因子:
--
通讯作者:
Moradian-Oldak J
Moradian-Oldak J
中科院分区:
其他
文献类型:
--
作者:
Moradian-Oldak J

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釉质是一种坚硬的纳米复合生物陶瓷,具有显著的弹性,可以保护哺乳动物的牙齿免受外部物理和化学损伤。釉质具有显著的力学性能与其层次化的结构组织和与底层牙本质的紧密联系有关。这种动态矿化系统为科学家提供了丰富的信息,使研究有机基质介导的生物矿化的基本原理成为可能,并有可能在材料科学和工程领域用于仿生材料的开发和设计。本章将简要概述釉质的层次结构和性质,以及釉质形成的过程和阶段。特别强调细胞外基质蛋白和蛋白水解酶的最新知识,以及基质成分的结构化学和它们可能的功能。本章最后将讨论牙釉质再生的潜力。
Enamel is a hard nanocomposite bioceramic with significant resilience that protects the mammalian tooth from external physical and chemical damages. The remarkable mechanical properties of enamel are associated with its hierarchical structural organization and its thorough connection with underlying dentin. This dynamic mineralizing system offers scientists a wealth of information that allows the study of basic principals of organic matrix-mediated biomineralization and can potentially be utilized in the fields of material science and engineering for development and design of biomimetic materials. This chapter will provide a brief overview of enamel hierarchical structure and properties as well as the process and stages of amelogenesis. Particular emphasis is given to current knowledge of extracellular matrix protein and proteinases, and the structural chemistry of the matrix components and their putative functions. The chapter will conclude by discussing the potential of enamel for regrowth.
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