Racial differences in health and cognition as a function of HIV among older adults.
Racial differences in health and cognition as a function of HIV among older adults.
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DOI：
10.1080/13854046.2021.1967449
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Senturk D
中科院分区：
文献类型：
--
作者：
Thames AD;Nunez R;Slavich GM;Irwin MR;Senturk D
本研究调查了380名50岁以上的HIV阳性（HIV+; n = 221）和HIV血清阴性（HIV-; n = 159）非洲裔美国人和欧洲裔美国人成年人的健康风险因素（使用Charlson Comorbid指数[CCI]）对认知结果的贡献。参与者是从艾滋病毒诊所和社区广告招募的。通过血清学检测确认了艾滋病毒状况。自我报告和病历审查被用来收集有关医疗sss合并症的信息。使用Charlson合并症指数（CCI）创建合并症评分。参与者被管理一个简短的认知测试电池。正如预期的那样，艾滋病毒感染者的健康风险更大。CCI评分存在HIV ×种族相互作用，例如在HIV +组中，欧洲裔美国人的CCI评分（M = 3.74; SD = 2.1）显著高于非洲裔美国人HIV +参与者（M = 2.70; SD = 1.9）。然而，在HIV-组中，非裔美国人的CCI评分（M = 2.20; SD = 1.1）显著高于HIV-欧洲裔美国人参与者（M = 1.80; SD = 1.2）。此外，与假设一致，在整个样本中，CCI评分与整体认知显著相关（β =-0.24，p = 0.02）。研究结果强调了在研究种族健康差异以及多种医疗风险如何与认知结果相关的研究中考虑艾滋病毒血清状态的重要性。神经心理学家评估艾滋病毒感染者应该考虑多种医学共病的存在如何导致随着年龄的增长认知能力下降。
The present study investigated the contribution of health risk factors (using the Charlson Comorbidity Index [CCI]) on cognitive outcomes in a sample of 380 HIV-positive (HIV+; n = 221) and HIV-seronegative (HIV−; n = 159) African American and European American adults aged 50+. Participants were recruited from HIV clinics and community advertisements. HIV status was confirmed by serological testing. Self-report and chart history review was used to gather information about medical sss-comorbidities. The Charlson Comorbidity Index (CCI) was used to create a comorbidity score. Participants were administered a brief cognitive test battery. As expected, health risks were greater among those with HIV. There was a HIV × Race interaction on CCI scores, such that in the HIV + group, European Americans had significantly higher CCI scores (M = 3.74; SD = 2.1) than African American HIV + participants (M = 2.70; SD = 1.9). However, in the HIV − group, African Americans had significantly higher CCI scores (M = 2.20; SD = 1.1) than HIV − European American participants (M = 1.80; SD = 1.2). Also, consistent with hypotheses, across the entire sample CCI score was significantly associated with global cognition (β = −.24, p = .02). Study results underscore the importance of considering HIV serostatus in studies examining racial disparities in health, and how multiple medical risks relate to cognitive outcomes. Neuropsychologists evaluating patients living with HIV should consider how the presence of multiple medical comorbidities may contribute to the course of cognitive decline as people age.
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DOI：
10.7196/samj.2019.v109i3.13367
发表时间：
2019-03-01
期刊：
SAMJ: South African Medical Journal
影响因子：
--
作者：
Dreyer, R;Viljoen, A J
通讯作者：
Viljoen, A J
影响因子：
5.6
作者：
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通讯作者：
LaVeist, Thomas A.
影响因子：
5.7
作者：
Duru, O. Kenrik;Bilik, Dori;Mangione, Carol M.
通讯作者：
Mangione, Carol M.
影响因子：
5.5
作者：
Clouston SA;Brewster P;Kuh D;Richards M;Cooper R;Hardy R;Rubin MS;Hofer SM
通讯作者：
Hofer SM
DOI：
10.1080/13854046.2015.1029974
发表时间：
2015
期刊：
The Clinical neuropsychologist
影响因子：
--
作者：
Arentoft A;Byrd D;Monzones J;Coulehan K;Fuentes A;Rosario A;Miranda C;Morgello S;Rivera Mindt M
通讯作者：
Rivera Mindt M