Differential effects of high-fish oil and high-lard diets on cells and cytokines involved in the inflammatory process in rat insulin-sensitive tissues.
Differential effects of high-fish oil and high-lard diets on cells and cytokines involved in the inflammatory process in rat insulin-sensitive tissues.
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DOI：
10.3390/ijms15023040
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发表时间：
2014-02-20
影响因子：
5.6
通讯作者：
Putti R
中科院分区：
文献类型：
--
作者：
Lionetti L;Mollica MP;Sica R;Donizzetti I;Gifuni G;Pignalosa A;Cavaliere G;Putti R
膳食脂肪来源可能会在长期过度喂养期间对胰岛素敏感组织炎症的发展产生不同的影响。考虑到 ω-3 脂肪酸的抗炎特性，本研究旨在通过评估血清和组织脂肪因子水平以及胰岛素敏感组织（白色脂肪组织、骨骼肌和肝脏）的组织学特征，比较长期高鱼油和高猪油饮食对肥胖相关炎症的影响。正如预期的那样，高猪油饮食会诱发全身和外周炎症以及胰岛素抵抗。相反，与高猪油饮食相比，高鱼油饮食导致全身炎症和胰岛素抵抗程度较低，这与脂肪细胞直径较小以及白色脂肪组织中转化生长因子β1（TGFβ1）免疫反应性较低有关。高鱼油饮食还可以降低骨骼肌和肝脏的异位脂质库、炎症程度和胰岛素抵抗。此外，平滑肌 α-肌动蛋白 (α-SMA) 和 TGFβ1 水平表明，高鱼油饮食可减弱肝脏中的肝星状细胞活化和纤维形成。在长期高脂肪喂养中用鱼油（ω-3 脂肪酸）替代猪油（饱和脂肪酸）可减轻全身和组织炎症的发展。
Dietary fat sources may differentially affect the development of inflammation in insulin-sensitive tissues during chronic overfeeding. Considering the anti-inflammatory properties of ω-3 fatty acids, this study aimed to compare the effects of chronic high-fish oil and high-lard diets on obesity-related inflammation by evaluating serum and tissue adipokine levels and histological features in insulin-sensitive tissues (white adipose tissue, skeletal muscle and liver). As expected, a high-lard diet induced systemic and peripheral inflammation and insulin resistance. Conversely, compared with a high-lard diet, a high-fish oil diet resulted in a lower degree of systemic inflammation and insulin resistance that were associated with a lower adipocyte diameter as well as lower immunoreactivity for transforming growth factor β 1 (TGFβ1) in white adipose tissue. A high-fish oil diet also resulted in a lower ectopic lipid depot, inflammation degree and insulin resistance in the skeletal muscle and liver. Moreover, a high-fish oil diet attenuated hepatic stellate cell activation and fibrogenesis in the liver, as indicated by the smooth muscle α-actin (α-SMA) and TGFβ1 levels. The replacement of lard (saturated fatty acids) with fish oil (ω-3 fatty acids) in chronic high-fat feeding attenuated the development of systemic and tissue inflammation.
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影响因子：
7.7
作者：
de Lange P;Cioffi F;Senese R;Moreno M;Lombardi A;Silvestri E;De Matteis R;Lionetti L;Mollica MP;Goglia F;Lanni A
通讯作者：
Lanni A
影响因子：
7
作者：
Calder, Philip C.
通讯作者：
Calder, Philip C.
影响因子：
8.2
作者：
Flachs, P;Mohamed-Ali, V;Kopecky, J
通讯作者：
Kopecky, J
DOI：
10.1073/pnas.0511167103
发表时间：
2006-03-28
影响因子：
11.1
作者：
Henderson, NC;Mackinnon, AC;Sethi, T
通讯作者：
Sethi, T
影响因子：
4.2
作者：
Ghafoorunissa;Ibrahim, A;Acharya, V
通讯作者：
Acharya, V