Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer.
Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer.
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DOI：
10.1016/j.annonc.2019.09.007
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Smith-Warner SA
中科院分区：
文献类型：
--
作者：
Genkinger JM;Wu K;Wang M;Albanes D;Black A;van den Brandt PA;Burke KA;Cook MB;Gapstur SM;Giles GG;Giovannucci E;Goodman GG;Goodman PJ;Håkansson N;Key TJ;Männistö S;Le Marchand L;Liao LM;MacInnis RJ;Neuhouser ML;Platz EA;Sawada N;Schenk JM;Stevens VL;Travis RC;Tsugane S;Visvanathan K;Wilkens LR;Wolk A;Smith-Warner SA
人们对晚期前列腺癌的病因知之甚少。很少有研究研究人体测量因素(例如，成年早期肥胖)与晚期前列腺癌风险的关系。我们进行了合并分析，以检查身体肥胖、身高和前列腺癌风险之间的关系。在830,772名男性中，确认了51,734例前列腺癌病例，包括4,762例晚期(T4/N1/M1或前列腺癌死亡)病例，2,915例晚期限制性病例(与晚期相同，但不包括导致死亡的局部癌症)，9,489例高级别病例，以及3,027例前列腺癌死亡。COX比例风险模型用于计算研究特定风险比(HR)和95%可信区间(CI)；结果用随机效应模型合并。未观察到成年早期体重指数与晚期前列腺癌、晚期限制性前列腺癌和高级别前列腺癌死亡率之间有统计学意义的相关性。基线体重指数与晚期前列腺癌(HR=1.3 0，95%CI=0.95~1.78)和前列腺癌死亡率(HR=1.5 2，95%CI=1.12~2.0 7)呈正相关，而体重指数≥为35.0 kg/m2和2 1~2 2.9 kg/m2。当同时考虑成年早期和基线体重指数时，观察到成年早期体重指数25.0 kg/m2和基线体重指数≥30.0 kg/m2的男性前列腺癌死亡风险比成年早期体重指数25.0 kg/m2和基线体重指数30.0 kg/m2高27%(95%CI=9-49%)。比较≥110 cm和90 cm的基线腰围和比较≥1.00和0.9的腰臀比，高级别前列腺癌风险显著增加14-16%，前列腺癌死亡风险显著增加20-39%。身高1.90米和1.65米相比，身高与晚期或进展性局限性前列腺癌和前列腺癌死亡率之间存在33-56%的潜在或显著相关风险。≥身高1.90米，身高1.65米。我们的发现表明，成年中后期的身高、总肥胖和中心性肥胖，而不是成年早期的肥胖，与晚期前列腺癌的风险有关。因此，保持健康的体重可能有助于预防晚期前列腺癌。
Advanced prostate cancer etiology is poorly understood. Few studies have examined associations of anthropometric factors (e.g., early adulthood obesity) with advanced prostate cancer risk. We performed pooled analyses to examine associations between body fatness, height and prostate cancer risk. Among 830,772 men, 51,734 incident prostate cancer cases were identified, including 4,762 advanced (T4/N1/M1 or prostate cancer deaths) cases, 2,915 advanced restricted (same as advanced, but excluding localized cancers that resulted in death) cases, 9,489 high grade cases, and 3,027 prostate cancer deaths. Cox proportional hazards models were used to calculate study-specific hazard ratios (HR) and 95% confidence intervals (CI); results were pooled using random effects models. No statistically significant associations were observed for BMI in early adulthood for advanced, advanced restricted, and high-grade prostate cancer and prostate cancer mortality. Positive associations were shown for BMI at baseline with advanced prostate cancer (HR=1.30, 95% CI=0.95-1.78) and prostate cancer mortality (HR=1.52, 95% CI=1.12-2.07) comparing BMI≥35.0kg/m2 with 21-22.9kg/m2. When considering early adulthood and baseline BMI together, a 27% higher prostate cancer mortality risk (95% CI=9-49%) was observed for men with BMI<25.0kg/m2 in early adulthood and BMI≥30.0kg/m2 at baseline compared to BMI<25.0kg/m2 in early adulthood and BMI<30.0kg/m2 at baseline. Baseline waist circumference, comparing ≥110cm with <90cm, and waist-to-hip ratio, comparing ≥1.00 with <0.90, were associated with significant 14-16% increases in high-grade prostate cancer risk and suggestive or significant 20-39% increases in prostate cancer mortality risk. Height was associated with suggestive or significant 33-56% risks of advanced or advanced restricted prostate cancer and prostate cancer mortality, comparing ≥1.90m with <1.65m. Our findings suggest that height and total and central adiposity in mid-to-later adulthood, but not early adulthood adiposity, are associated with risk of advanced forms of prostate cancer. Thus, maintenance of healthy weight may help prevent advanced prostate cancer.
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影响因子：
6.4
作者：
Bassett, Julie K.;Severi, Gianluca;Giles, Graham G.
通讯作者：
Giles, Graham G.
影响因子：
2
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DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
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作者：
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Wolk, A.
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作者：
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通讯作者：
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