Communication from Learned to Innate Olfactory Processing Centers Is Required for Memory Retrieval in Drosophila.
Communication from Learned to Innate Olfactory Processing Centers Is Required for Memory Retrieval in Drosophila.
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DOI：
10.1016/j.neuron.2018.08.037
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发表时间：
2018-11-07
期刊：
影响因子：
16.2
通讯作者：
Jefferis GSXE
中科院分区：
文献类型：
--
作者：
Dolan MJ;Belliart-Guérin G;Bates AS;Frechter S;Lampin-Saint-Amaux A;Aso Y;Roberts RJV;Schlegel P;Wong A;Hammad A;Bock D;Rubin GM;Preat T;Plaçais PY;Jefferis GSXE
对感官刺激的行为反应可能取决于习得和先天的神经元表征。这些电路如何相互作用以产生适当的行为尚不清楚。在果蝇中，侧角 (LH) 和蘑菇体 (MB) 被认为分别介导先天和后天的嗅觉行为，尽管 LH 功能尚未直接测试。在这里，我们确定了两种 LH 细胞类型（PD2a1 和 PD2b1），它们从 MB 输出神经元接收输入，以回忆厌恶的嗅觉记忆。这些神经元是厌恶记忆检索所必需的，并通过训练进行调节。连接组学数据表明 PD2a1 和 PD2b1 神经元还接收来自食物气味编码神经元的直接输入。与此一致的是，PD2a1 和 PD2b1 对于某些气味的非习得性吸引也是必需的，这表明这些神经元具有双重行为作用。这提供了一种电路机制，通过该机制，习得的和先天的嗅觉信息可以在已识别的神经元中相互作用，以产生适当的行为。特定的果蝇侧角神经元介导对食物气味的先天吸引力相同的神经元从蘑菇体接收塑料气味信息联想学习后的回忆取决于对侧角神经元驱动力的减少用于整合习得和先天气味表征的连接组学电路感觉刺激可以参与习得和先天行为。多兰等人。识别果蝇中直接整合未学习和可塑气味表征的神经元；它们是对食物气味的本能反应所必需的，但也需要习得的厌恶回忆。
The behavioral response to a sensory stimulus may depend on both learned and innate neuronal representations. How these circuits interact to produce appropriate behavior is unknown. In Drosophila, the lateral horn (LH) and mushroom body (MB) are thought to mediate innate and learned olfactory behavior, respectively, although LH function has not been tested directly. Here we identify two LH cell types (PD2a1 and PD2b1) that receive input from an MB output neuron required for recall of aversive olfactory memories. These neurons are required for aversive memory retrieval and modulated by training. Connectomics data demonstrate that PD2a1 and PD2b1 neurons also receive direct input from food odor-encoding neurons. Consistent with this, PD2a1 and PD2b1 are also necessary for unlearned attraction to some odors, indicating that these neurons have a dual behavioral role. This provides a circuit mechanism by which learned and innate olfactory information can interact in identified neurons to produce appropriate behavior. Specific Drosophila lateral horn neurons mediate innate attraction to food odors The same neurons receive plastic odor information from the mushroom body Recall after associative learning depends on reduced drive to lateral horn neurons Connectomics circuit for integration of learned and innate odor representations Sensory stimuli can engage both learned and innate behaviors. Dolan et al. identify neurons in Drosophila that directly integrate unlearned and plastic odor representations; they are required for innate approach to food odors but also learned aversive recall.
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影响因子：
8.8
作者：
Diao F;Ironfield H;Luan H;Diao F;Shropshire WC;Ewer J;Marr E;Potter CJ;Landgraf M;White BH
通讯作者：
White BH
影响因子：
7.7
作者：
Aso Y;Hattori D;Yu Y;Johnston RM;Iyer NA;Ngo TT;Dionne H;Abbott LF;Axel R;Tanimoto H;Rubin GM
通讯作者：
Rubin GM
影响因子：
8.8
作者：
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通讯作者：
Zugates, Christopher T.
影响因子：
9.2
作者：
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通讯作者：
Hwang, Jenn-Kang
影响因子：
64.5
作者：
Cohn R;Morantte I;Ruta V
通讯作者：
Ruta V