Vagal modulation of resting heart rate in rats: the role of stress, psychosocial factors, and physical exercise.
Vagal modulation of resting heart rate in rats: the role of stress, psychosocial factors, and physical exercise.
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DOI：
10.3389/fphys.2014.00118
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发表时间：
2014
影响因子：
4
通讯作者：
Sgoifo A
中科院分区：
文献类型：
--
作者：
Carnevali L;Sgoifo A
在人类中，静息心率 (HR) 的迷走神经调节水平存在很大的个体差异。高水平是公认的心脏健康指标，而低水平则被认为是心血管发病和死亡的重要危险因素。据认为，有几个因素对这种个体间差异有显着影响。虽然定期的体育锻炼似乎会导致静息迷走神经张力增加，但慢性生活压力和负面情绪和人格特质等社会心理因素似乎与迷走神经退缩有关。临床前研究一直试图阐明这种关系，并深入了解迷走神经张力受损/增强的神经生物学机制。本文重点关注大鼠研究，探讨压力、心理社会因素和体育锻炼对静息心率迷走神经调节的影响。结果讨论涉及：（i）静息迷走神经张力、心脏应激反应性和心律失常脆弱性的个体差异； (ii) 阐明静息迷走神经张力的神经生物学决定因素。
In humans, there are large individual differences in the levels of vagal modulation of resting heart rate (HR). High levels are a recognized index of cardiac health, whereas low levels are considered an important risk factor for cardiovascular morbidity and mortality. Several factors are thought to contribute significantly to this inter-individual variability. While regular physical exercise seems to induce an increase in resting vagal tone, chronic life stress, and psychosocial factors such as negative moods and personality traits appear associated with vagal withdrawal. Preclinical research has been attempting to clarify such relationships and to provide insights into the neurobiological mechanisms underlying vagal tone impairment/enhancement. This paper focuses on rat studies that have explored the effects of stress, psychosocial factors and physical exercise on vagal modulation of resting HR. Results are discussed with regard to: (i) individual differences in resting vagal tone, cardiac stress reactivity and arrhythmia vulnerability; (ii) elucidation of the neurobiological determinants of resting vagal tone.
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影响因子：
2.9
作者：
Björkqvist, K
通讯作者：
Björkqvist, K
影响因子：
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作者：
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3.3
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Carnevali, Luca;Trombini, Mimosa;Sgoifo, Andrea
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作者：
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影响因子：
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作者：
Carnevali, Luca;Mastorci, Francesca;Sgoifo, Andrea
通讯作者：
Sgoifo, Andrea