Vestibular modulation of muscle sympathetic nerve activity by the utricle during sub-perceptual sinusoidal linear acceleration in humans
Vestibular modulation of muscle sympathetic nerve activity by the utricle during sub-perceptual sinusoidal linear acceleration in humans
复制标题
人类亚知觉正弦线性加速过程中椭圆囊对肌肉交感神经活动的前庭调节
DOI：
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
V. Macefield
中科院分区：
文献类型：
--
作者：
E. Hammam;C. L. Hau;Kwok;K. Kwok;V. Macefield
摘要
我们评估了前庭椭圆囊在正弦线性加速过程中调节肌肉交感神经活动（MSNA）的能力，其幅度从不可感知到清晰可感知。受试者（n = 16）坐在一个密封的房间里，消除视觉线索，安装在一个线性电机，可以提供峰值正弦加速度30 mG的前后方向。受试者坐在软垫椅子上，颈部和头部垂直支撑，从而最大限度地减少体感提示，面向前方的运动方向。在受试者未知的时间，以随机顺序的振幅（1.25、2.5、5、10、20和30 mG），以0.2 Hz的恒定频率，施加每个正弦运动块。通过插入腓总神经肌束的钨微电极记录MSNA。受试者使用与运动轴对齐的线性电位计来指示任何感知到的运动，并将其与实际房间运动的加速度计信号进行比较。平均而言，67%的正确运动检测直到6.5 mG才发生，正确运动方向的知识约为10 mG。交叉相关分析显示，即使在受试者无法感知的加速度（1.25-5 mG）下，MSNA也具有有效的正弦调制。调制指数随加速度幅度呈线性增加，30 mG时的调制指数（25.3 ± 3.7%）显著高于1.25 mG时的调制指数（15.5 ± 1.2%）。我们的结论是，前庭椭圆囊的选择性激活导致MSNA的明显调制，即使在远低于感知阈值的水平，并提供进一步的证据支持前庭交感神经反射在人类心血管控制的重要性。
Abstract
We assessed the capacity for the vestibular utricle to modulate muscle sympathetic nerve activity (MSNA) during sinusoidal linear acceleration at amplitudes extending from imperceptible to clearly perceptible. Subjects (n = 16) were seated in a sealed room, eliminating visual cues, mounted on a linear motor that could deliver peak sinusoidal accelerations of 30 mG in the antero-posterior direction. Subjects sat on a padded chair with their neck and head supported vertically, thereby minimizing somatosensory cues, facing the direction of motion in the anterior direction. Each block of sinusoidal motion was applied at a time unknown to subjects and in a random order of amplitudes (1.25, 2.5, 5, 10, 20 and 30 mG), at a constant frequency of 0.2 Hz. MSNA was recorded via tungsten microelectrodes inserted into muscle fascicles of the common peroneal nerve. Subjects used a linear potentiometer aligned to the axis of motion to indicate any perceived movement, which was compared with the accelerometer signal of actual room movement. On average, 67 % correct detection of movement did not occur until 6.5 mG, with correct knowledge of the direction of movement at ~10 mG. Cross-correlation analysis revealed potent sinusoidal modulation of MSNA even at accelerations subjects could not perceive (1.25–5 mG). The modulation index showed a positive linear increase with acceleration amplitude, such that the modulation was significantly higher (25.3 ± 3.7 %) at 30 mG than at 1.25 mG (15.5 ± 1.2 %). We conclude that selective activation of the vestibular utricle causes a pronounced modulation of MSNA, even at levels well below perceptual threshold, and provides further evidence in support of the importance of vestibulosympathetic reflexes in human cardiovascular control.
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DOI：
10.1152/ajpheart.2000.279.5.h2399
发表时间：
2000-11
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
C. Ray
通讯作者：
C. Ray
影响因子：
3.3
作者：
Jian, BJ;Cotter, LA;Yates, BJ
通讯作者：
Yates, BJ
影响因子：
2.5
作者：
B. J. Yates;Alan D. Miller
通讯作者：
B. J. Yates;Alan D. Miller
DOI：
10.1152/ajpregu.2000.279.1.r109
发表时间：
2000-07-01
影响因子：
2.8
作者：
Kerman, IA;Yates, BJ;McAllen, RM
通讯作者：
McAllen, RM