Distal to proximal development of peripheral nerves requires the expression of neurofilament heavy.
Distal to proximal development of peripheral nerves requires the expression of neurofilament heavy.
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DOI：
10.1016/j.neuroscience.2010.07.014
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发表时间：
2010-09-29
期刊：
影响因子：
3.3
通讯作者：
Garcia, M. L.
中科院分区：
文献类型：
--
作者：
Shen, H.;Barry, D. M.;Garcia, M. L.
在放射状生长开始时，神经丝可能主要由神经丝轻和中等组成，因为神经丝重的表达在发育上延迟。为了更好地理解神经丝重在构建轴突中的作用，在坐骨神经的近端和远端段以及沿着膈神经的整个长度测量轴突直径和神经丝组织。神经丝的缺失严重减少了近端神经节段的轴突直径和神经丝数量。然而，近端膈神经段的神经丝间距大于远端膈神经段。两者合计，这些结果表明，神经丝重的损失减少了近端轴突节段的径向生长，通过减少神经丝的积累。由于神经丝重表达发育延迟，这些结果表明，没有神经丝重，神经丝网络建立在远端到近端的梯度，可能允许远端轴突段发展之前，近端段。
At the initiation of radial growth, neurofilaments are likely to consist primarily of neurofilament light and medium as neurofilament heavy expression is developmentally delayed. To better understand the role of neurofilament heavy in structuring axons, axonal diameter and neurofilament organization were measured in proximal and distal segments of the sciatic nerve and along the entire length of the phrenic nerve. Deletion of neurofilament heavy reduced axonal diameters and neurofilament number in proximal nerve segments. However, neurofilament spacing was greater in proximal versus distal phrenic nerve segments. Taken together, these results suggest that loss of neurofilament heavy reduces radial growth in proximal axonal segments by reducing the accumulation of neurofilaments. As neurofilament heavy expression is developmentally delayed, these results suggest that without neurofilament heavy, the neurofilament network is established in a distal to proximal gradient perhaps to allow distal axonal segments to develop prior to proximal segments.
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