Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?

Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?
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DOI:
10.1080/14760584.2021.1899817
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发表时间:
2021-04
影响因子:
6.2
通讯作者:
Pal S
Pal S
中科院分区:
医学2区
文献类型:
--
作者:
de la Maza LM;Darville TL;Pal S

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沙眼是一种由沙眼衣原体引起的眼部疾病,早在100年前人们就开始尝试预防沙眼。20世纪60年代人们认识到沙眼原体也是一种常见的性传播病原体,这进一步刺激了研制疫苗的研究。然而,直到最近才成功完成了沙眼衣原体疫苗预防生殖器感染的一期临床试验。在此,我们讨论衣原体疫苗学方面取得的最重大进展,主要集中在过去5年中,并就可以采取哪些步骤加快研制成功的疫苗提供建议。为了深入回顾以前在衣原体疫苗学方面的工作,我们推荐以下参考文献。
Attempts to protect against trachoma, an ocular disease caused by Chlamydia trachomatis, started a 100 years ago. The realization in the 1960’s that C. trachomatis was also a common sexually transmitted pathogen further stimulated research to implement a vaccine. However, it is only recently that a phase 1 clinical trial of a C. trachomatis vaccine to protect against genital infections was successfully completed. Here, we discuss the most significant advances that have occurred in Chlamydia vaccinology, focusing mainly in the last 5 years, and provide advice on what steps can be taken to expedite the formulation of a successful vaccine. For in depth review of previous work in Chlamydia vaccinology we recommend the following references.
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