Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?
Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?
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DOI:
10.1080/14760584.2021.1899817
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发表时间:
2021-04
影响因子:
6.2
通讯作者:
Pal S
中科院分区:
文献类型:
--
作者:
de la Maza LM;Darville TL;Pal S
Attempts to protect against trachoma, an ocular disease caused by Chlamydia trachomatis, started a 100 years ago. The realization in the 1960’s that C. trachomatis was also a common sexually transmitted pathogen further stimulated research to implement a vaccine. However, it is only recently that a phase 1 clinical trial of a C. trachomatis vaccine to protect against genital infections was successfully completed. Here, we discuss the most significant advances that have occurred in Chlamydia vaccinology, focusing mainly in the last 5 years, and provide advice on what steps can be taken to expedite the formulation of a successful vaccine. For in depth review of previous work in Chlamydia vaccinology we recommend the following references.
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