Age-Specific Seasonal Influenza Vaccine Effectiveness against Different Influenza Subtypes in the Hospitalized Population in Lithuania during the 2015-2019 Influenza Seasons.
Age-Specific Seasonal Influenza Vaccine Effectiveness against Different Influenza Subtypes in the Hospitalized Population in Lithuania during the 2015-2019 Influenza Seasons.
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2015 - 2019年流感季节，针对立陶宛住院人口中不同流感亚型的特定年龄季节性流感疫苗有效性。
DOI：
10.3390/vaccines9050455
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发表时间：
2021-05-04
期刊：
影响因子：
7.8
通讯作者：
Study Group
中科院分区：
文献类型：
--
作者：
Kuliese M;Mickiene A;Jancoriene L;Zablockiene B;Gefenaite G;Study Group
背景：由于流感病毒性质的变化，需要持续监测季节性流感疫苗的有效性(SIVE)，它支持关于疫苗成分年度更新的决定。在立陶宛的四个流感季节，针对住院人群中的不同流感亚型评估了特定年龄的SIVE。方法：采用试验阴性病例对照研究设计。其95%可信区间(95%CI)为(1-优势比(OR))×100%。结果：18岁人群对甲型H1N1流感、甲型H1N1流感和B/Yamagata流感的校正免疫效果分别为78.0%(95%CI：1.7；95.1%)、88.6%(95%CI：−47.4；99.1%)和76.8%(95%CI：−109.9；97.4%)。在65岁及以上人群中，甲型流感、乙型流感和乙型流感的校正SIVE分别为22.6%(95%CI：−36.5；56.1%)、75.3%(95%CI：12.2；93.1%)和73.1%(95%CI：3.2；92.5%)。在18岁至的患者中，对甲型H3N2型流感的未调整免疫效果为44.8%(95%CI：−171.0；88.8%)，在65岁及以上患者中为5.0%(95%CI：−74.5；48.3%)。结论：点数估计表明，18岁的参与者对甲型流感的SIVE很高，65岁及以上的人对B型流感和B/Yamagata流感的抵抗力较高。
Background: Continuous monitoring of seasonal influenza vaccine effectiveness (SIVE) is needed due to the changing nature of influenza viruses and it supports the decision on the annual update of vaccine composition. Age-specific SIVE was evaluated against different influenza subtypes in the hospitalized population in Lithuania during four influenza seasons. Methods: A test-negative case-control study design was used. SIVE and its 95% confidence intervals (95% CI) were calculated as (1 – odds ratio (OR)) × 100%. Results: Adjusted SIVE in 18–64-year-old individuals against influenza A, A(H1N1)pdm09 and B/Yamagata were 78.0% (95% CI: 1.7; 95.1%), 88.6% (95% CI: −47.4; 99.1%), and 76.8% (95% CI: −109.9; 97.4%), respectively. Adjusted SIVE in individuals aged 65 years and older against influenza A, influenza B, and B/Yamagata were 22.6% (95% CI: −36.5; 56.1%), 75.3% (95% CI: 12.2; 93.1%) and 73.1% (95% CI: 3.2; 92.5%), respectively. Unadjusted SIVE against influenza A(H3N2) among 18–64-year-old patients was 44.8% (95% CI: −171.0; 88.8%) and among those aged 65 years and older was 5.0% (95% CI: −74.5; 48.3%). Conclusions: Point estimates suggest high SIVE against influenza A in 18–64-year-old participants, and against influenza B and B/Yamagata in those 65 years old and older.
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影响因子：
5.5
作者：
Castilla, Jesus;Eugenia Portillo, Maria;Martinez-Baz, Ivan
通讯作者：
Martinez-Baz, Ivan
影响因子：
3.7
作者：
Martirosyan L;Paget WJ;Jorgensen P;Brown CS;Meerhoff TJ;Pereyaslov D;Mott JA;EuroFlu group
通讯作者：
EuroFlu group
影响因子：
5.5
作者：
Puig-Barbera, Joan;Guglieri-Lopez, Beatriz;Diez-Domingo, Javier
通讯作者：
Diez-Domingo, Javier
影响因子：
5.5
作者：
Foppa, Ivo M.;Haber, Michael;Shay, David K.
通讯作者：
Shay, David K.
DOI：
10.1007/s10096-017-3135-0
发表时间：
2018-02-01
影响因子：
4.5
作者：
Khoury, J.;Szwarcwort, M.;Neuberger, A.
通讯作者：
Neuberger, A.