The community impact of the 2009 influenza pandemic in the WHO European region: a comparison with historical seasonal data from 28 countries.
The community impact of the 2009 influenza pandemic in the WHO European region: a comparison with historical seasonal data from 28 countries.
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DOI：
10.1186/1471-2334-12-36
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发表时间：
2012-02-10
影响因子：
3.7
通讯作者：
EuroFlu group
中科院分区：
文献类型：
--
作者：
Martirosyan L;Paget WJ;Jorgensen P;Brown CS;Meerhoff TJ;Pereyaslov D;Mott JA;EuroFlu group
世界最近经历了21世纪第一次流感大流行，从2009年6月到2010年8月持续了14个月。本研究旨在比较2009年甲型H1N1流感大流行冬季波与世卫组织欧洲区域各国历史流感季节的时间、地理传播和社区影响。我们通过比较该地区各国在过去七个流感季节中流感活动的中位数高峰来评估大流行的时间。流感活动的高峰是由两名独立的研究人员使用预定义的规则选择的。通过将纳入国家的流感活动高峰周与每个国家中心点的经度和纬度相关联来评估地理传播。为了评估大流行性流感对社区的影响，我们构建了线性回归模型，将各国在大流行季节报告的总流感样疾病（ILI）或急性呼吸道感染（ARI）发病率与前六个流感季节的发病率进行比较。结果发现，流感活动性在大流行期间达到高峰，比前6个季节平均提前10.5周（95% CI 6.4 ~ 14.2），甲型H1N1流感大流行病毒在西部呈西向东传播。回归分析显示，28个国家中有19个国家的ILI或ARI总发病率不高于历史发病率。然而，在有特定年龄数据的国家中，20个国家中有11个国家0-4岁和/或5-14岁年龄组的咨询率明显较高。利用常规流感监测数据，我们发现与该地区的历史季节相比，大流行性流感具有几个不同的特征。它到达较早，在大多数国家造成儿童门诊就诊人数显著增加，并遵循以前在甲型H3N2流感病毒占主导地位的某些流感季节观察到的从西向东传播。本研究结果有助于了解2009年流感大流行的流行病学，并可用于大流行防范规划。
The world has recently experienced the first influenza pandemic of the 21st century that lasted 14 months from June 2009 to August 2010. This study aimed to compare the timing, geographic spread and community impact during the winter wave of influenza pandemic A (H1N1) 2009 to historical influenza seasons in countries of the WHO European region. We assessed the timing of pandemic by comparing the median peak of influenza activity in countries of the region during the last seven influenza seasons. The peaks of influenza activity were selected by two independent researchers using predefined rules. The geographic spread was assessed by correlating the peak week of influenza activity in included countries against the longitude and latitude of the central point in each country. To assess the community impact of pandemic influenza, we constructed linear regression models to compare the total and age-specific influenza-like-illness (ILI) or acute respiratory infection (ARI) rates reported by the countries in the pandemic season to those observed in the previous six influenza seasons. We found that the influenza activity reached its peak during the pandemic, on average, 10.5 weeks (95% CI 6.4-14.2) earlier than during the previous 6 seasons in the Region, and there was a west to east spread of pandemic A(H1N1) influenza virus in the western part of the Region. A regression analysis showed that the total ILI or ARI rates were not higher than historical rates in 19 of the 28 countries. However, in countries with age-specific data, there were significantly higher consultation rates in the 0-4 and/or 5-14 age groups in 11 of the 20 countries. Using routine influenza surveillance data, we found that pandemic influenza had several differential features compared to historical seasons in the region. It arrived earlier, caused significantly higher number of outpatient consultations in children in most countries and followed west to east spread that was previously observed during some influenza seasons with dominant A (H3N2) ifluenza viruses. The results of this study help to understand the epidemiology of 2009 influenza pandemic and can be used for pandemic preparedness planning.
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影响因子：
3.7
作者：
Paget, John;Marquet, Richard;van der Velden, Koos
通讯作者：
van der Velden, Koos
影响因子：
11.4
作者：
Kelly, Heath A.;Grant, Kristina A.;Smith, David
通讯作者：
Smith, David
影响因子：
9.8
作者：
Holmes EC;Ghedin E;Miller N;Taylor J;Bao Y;St George K;Grenfell BT;Salzberg SL;Fraser CM;Lipman DJ;Taubenberger JK
通讯作者：
Taubenberger JK
影响因子：
11.8
作者：
Carcione, Dale;Giele, Carolien;Effler, Paul
通讯作者：
Effler, Paul
影响因子：
2.2
作者：
Deckers, JGM;Paget, WJ;Fleming, DM
通讯作者：
Fleming, DM