Clinical characteristics of comorbid obsessive-compulsive disorder and bipolar disorder in children and adolescents.
Clinical characteristics of comorbid obsessive-compulsive disorder and bipolar disorder in children and adolescents.
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DOI：
10.1111/j.1399-5618.2010.00795.x
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发表时间：
2010-03
影响因子：
5.4
通讯作者：
Geller D
中科院分区：
文献类型：
--
作者：
Joshi G;Wozniak J;Petty C;Vivas F;Yorks D;Biederman J;Geller D
探讨青少年双相情感障碍（BPD）与强迫症（OCD）的双向共病，并在相互共病和确定状态的背景下，研究两种疾病的症状特征和临床相关性。使用临床、标量评估和结构化诊断访谈对同时确定的两个连续转介的青年（6-17岁）进行BPD和OCD研究的比较。共有21%（17/82）的BPD受试者和15%（19/125）的OCD受试者符合DSM-III-R两种疾病的诊断标准。在存在BPD的情况下，患有OCD的青少年更频繁地经历囤积/储蓄强迫症和强迫行为，并伴有更多的合并症、更差的整体功能和更高的住院率，这是BPD的特征。多重焦虑障碍（≥3种），特别是广泛性焦虑障碍和社交恐惧症，在强迫症和BPD合并症中出现的频率高于其他情况。在同时患有强迫症和BPD的受试者中，确定的原发障碍与发病更早和更严重的损害相关。在青少年中观察到的BPD和OCD的合并症发生率出乎意料的高，与最初的确定诊断无关。在患有强迫症和BPD合并症的青少年中，每种疾病的临床特征都是真实的，并且与他们在没有相互合并症的青少年中的临床表现相似，除了强迫症和囤积/储蓄强迫症的风险增加以及与其他焦虑症的合并症。
To explore bidirectional comorbidity between bipolar disorder (BPD) and obsessive-compulsive disorder (OCD) in youth and to examine the symptom profile and clinical correlates of both the disorders in the context of reciprocal comorbidity and ascertainment status. Two samples of consecutively referred youth (ages 6–17 years) ascertained contemporaneously for respective studies of BPD and OCD were compared using clinical and scalar assessment and structured diagnostic interviews. A total of 21% (17/82) of the BPD subjects and 15% (19/125) of the OCD subjects met DSM-III-R diagnostic criteria for both disorders. In the presence of BPD, youth with OCD more frequently experienced hoarding/saving obsessions and compulsions along with a clinical profile of greater comorbidity, poorer global functioning and higher rate of hospitalization that is characteristic of BPD. Multiple anxiety disorders (≥3), especially generalized anxiety disorder and social phobia, were present at a higher frequency when OCD and BPD were comorbid than otherwise. In subjects with comorbid OCD and BPD, the primary disorder of ascertainment was associated with an earlier onset and more severe impairment. An unexpectedly high rate of comorbidity between BPD and OCD was observed in youth irrespective of primary ascertainment diagnosis. In youth with comorbid OCD and BPD, the clinical characteristics of each disorder run true and are analogues to their clinical presentation in youth without reciprocal comorbidity, with the exception of increased risk for obsessions and compulsions of hoarding/saving and comorbidity with other anxiety disorders.
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影响因子：
6.6
作者：
Hantouche, EG;Angst, J;Akiskal, HS
通讯作者：
Akiskal, HS
影响因子：
6.6
作者：
KRUGER, S;COOKE, RG;PERSAD, E
通讯作者：
PERSAD, E
影响因子：
6.6
作者：
Biederman, J;Faraone, SV;George, P
通讯作者：
George, P
影响因子：
17.7
作者：
Johnson, JG;Cohen, P;Brook, JS
通讯作者：
Brook, JS
DOI：
10.1097/00004583-199511000-00008
发表时间：
1995-11-01
影响因子：
13.3
作者：
DOUGLASS, HM;MOFFITT, TE;SILVA, P
通讯作者：
SILVA, P