Membrane structure formation induced by two types of banana-shaped proteins.
Membrane structure formation induced by two types of banana-shaped proteins.
复制标题
两种香蕉形蛋白诱导的膜结构形成。
作者：
H. Noguchi;J. Fournier
通过分析理论和粗粒度模拟研究了香蕉形棒状蛋白在膜上的组装以及相关的膜形状转换。膜介导的两个香蕉形夹杂物之间的相互作用理论上推导出固定的各向异性曲率的基础上，无论是零表面张力和有限的表面张力使用点的形式主义。在更大的尺度上，这种棒状夹杂物的组件之间的相互作用的分析确定。无网格膜模拟进行了大量的夹杂物的存在下，两种类型，对应于弯曲杆的曲率相反，无论是平膜和囊泡。相同类型的杆聚集成垂直于杆轴的线性组件，导致膜管。然而，另一类型的杆，即具有相反曲率的杆，被吸引到这些组件的横向侧，并且稳定直的隆起结构，防止隆起。当这两种类型的杆具有几乎相反的曲率时，凸起彼此吸引，形成条纹结构。正表面张力被发现稳定条纹的形成。模拟结果与理论预测吻合得很好，提供了模型的点状曲率按比例缩小，以考虑模拟杆的有效柔性。
The assembly of banana-shaped rodlike proteins on membranes and the associated membrane shape transformations are investigated by analytical theory and coarse-grained simulations. The membrane-mediated interactions between two banana-shaped inclusions are derived theoretically using a point-like formalism based on fixed anisotropic curvatures, both for zero surface tension and for finite surface tension. On a larger scale, the interactions between the assemblies of such rodlike inclusions are determined analytically. Meshless membrane simulations are performed in the presence of a large number of inclusions of two types, corresponding to the curved rods of opposite curvatures, both for flat membranes and vesicles. Rods of the same type aggregate into linear assemblies perpendicular to the rod axis, leading to membrane tubulation. However, rods of the other type, those of opposite curvature, are attracted to the lateral sides of these assemblies, and stabilize a straight bump structure that prevents tubulation. When the two types of rods have almost opposite curvatures, the bumps attract one another, forming a striped structure. Positive surface tension is found to stabilize stripe formation. The simulation results agree well with the theoretical predictions provided the point-like curvatures of the model are scaled-down to account for the effective flexibility of the simulated rods.
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影响因子：
19
作者：
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通讯作者：
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影响因子：
3.4
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通讯作者：
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通讯作者：
Mizuno N
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3.4
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