The zoonotic potential of daptomycin non-susceptible enterococci.

The zoonotic potential of daptomycin non-susceptible enterococci.
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DOI:
10.1111/zph.12091
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发表时间:
2015-03
影响因子:
2.4
通讯作者:
Kelesidis T
Kelesidis T
中科院分区:
农林科学2区
文献类型:
--
作者:
Kelesidis T

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达托霉素不敏感肠球菌(DNSE)是一个新出现的临床问题。关于新的DNSE感染是如何发展的或与之相关的风险因素,人们知之甚少。确定与新发DNSE感染相关的危险因素将有助于理解达托霉素不敏感的机制。与世界各地的动物接触的人类面临携带多重耐药细菌的风险。在此,我综述了支持这一假说的科学证据,即达托霉素不敏感基因在动物和人类之间的运输可能是肠球菌发生新生达托霉素不敏感的一个可能机制。
Daptomycin non-susceptible Enterococcus (DNSE) is an emerging clinical problem. Little is known about how de novo DNSE infections develop or the risk factors associated with them. Determining risk factors associated with de novo DNSE infections will aid in understanding the mechanisms of daptomycin non-susceptibility. Humans in contact with animals worldwide are at risk of carriage of multidrug-resistant bacteria. Herein, I review the scientific evidence that supports the hypothesis that transport of daptomycin non-susceptibility genes between animals and humans may be a possible mechanism for development of de novo daptomycin non-susceptibility in enterococci.
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