Progress in molecular imaging in endoscopy and endomicroscopy for cancer imaging.
Progress in molecular imaging in endoscopy and endomicroscopy for cancer imaging.
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DOI：
10.1260/2040-2295.4.1.1
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发表时间：
2013
影响因子：
--
通讯作者：
Wang TD
中科院分区：
文献类型：
--
作者：
Khondee S;Wang TD
成像是有效癌症管理的重要工具。内窥镜是用于在中空器官中执行体内成像的重要医疗器械。通过使用内窥镜进行监测，可以实现癌症的早期检测，并已被证明可以降低死亡率并改善预后。最近，内窥镜仪器取得了很大的进步，包括光学设计、光源、光纤、微型扫描仪和多模式系统的新发展，从而提高了分辨率、更大的组织穿透力和多光谱成像。此外，在开发高度特异性的光学探针方面也取得了进展，从而提高了对分子靶标的特异性。这些新的内窥镜仪器与分子探针的集成为显著改善患者结局提供了独特的机会，并有可能进一步改善早期检测、图像引导治疗、靶向治疗和个性化医疗。这项工作总结了当前和不断发展的内窥镜技术，并提供了各种有前途的光学分子探针的概述。
Imaging is an essential tool for effective cancer management. Endoscopes are important medical instruments for performing in vivo imaging in hollow organs. Early detection of cancer can be achieved with surveillance using endoscopy, and has been shown to reduce mortality and to improve outcomes. Recently, great advancements have been made in endoscopic instruments, including new developments in optical designs, light sources, optical fibers, miniature scanners, and multimodal systems, allowing for improved resolution, greater tissue penetration, and multispectral imaging. In addition, progress has been made in the development of highly-specific optical probes, allowing for improved specificity for molecular targets. Integration of these new endoscopic instruments with molecular probes provides a unique opportunity for significantly improving patient outcomes and has potential to further improve early detection, image guided therapy, targeted therapy, and personalized medicine. This work summarizes current and evolving endoscopic technologies, and provides an overview of various promising optical molecular probes.
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影响因子：
10.4
作者：
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通讯作者：
Hardman R
影响因子：
51.1
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3.5
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作者：
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通讯作者：
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2.8
作者：
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通讯作者：
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