Microbiota dynamics, metabolic and immune interactions in the cervicovaginal environment and their role in spontaneous preterm birth.
Microbiota dynamics, metabolic and immune interactions in the cervicovaginal environment and their role in spontaneous preterm birth.
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DOI：
10.3389/fimmu.2023.1306473
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发表时间：
2023
影响因子：
7.3
通讯作者：
PRECISE Network
中科院分区：
文献类型：
--
作者：
Onyango S;Mi JD;Koech A;Okiro P;Temmerman M;von Dadelszen P;Tribe RM;Omuse G;PRECISE Network
宫颈阴道微生物群的差异与自发性早产（sPTB）有关，这是婴儿发病率和死亡率的重要原因。虽然建立宫颈阴道微生物群和sPTB之间的直接因果关系仍然具有挑战性，但测序技术的最新进展促进了可能与sPTB相关的微生物标志物的鉴定。尽管研究结果存在差异，但反复观察表明，sPTB与整个妊娠期更多样化和更不稳定的阴道微生物群相关。假设sPTB风险可能通过复杂的宿主-微生物相互作用而不是由于单一微生物分类群或广泛的群落状态的存在而改变。尽管如此，乳酸杆菌优势通常与长期结局相关，并通过产生乳酸/维持排除其他病原微生物的低pH值来促进健康的阴道环境。此外，宿主的先天免疫和宫颈阴道微生物群之间的代谢相互作用，如细菌素的产生和蛋白水解酶的使用，对微生物种群、活动和宿主免疫应答产生深远影响。这些相互作用共同影响怀孕结果。本文旨在总结宫颈阴道环境和微生物群动力学的复杂性，以及与细菌性阴道病和sPTB的关系。还考虑了益生菌如何减轻sPTB和细菌性阴道病的风险。
Differences in the cervicovaginal microbiota are associated with spontaneous preterm birth (sPTB), a significant cause of infant morbidity and mortality. Although establishing a direct causal link between cervicovaginal microbiota and sPTB remains challenging, recent advancements in sequencing technologies have facilitated the identification of microbial markers potentially linked to sPTB. Despite variations in findings, a recurring observation suggests that sPTB is associated with a more diverse and less stable vaginal microbiota across pregnancy trimesters. It is hypothesized that sPTB risk is likely to be modified via an intricate host-microbe interactions rather than due to the presence of a single microbial taxon or broad community state. Nonetheless, lactobacilli dominance is generally associated with term outcomes and contributes to a healthy vaginal environment through the production of lactic acid/maintenance of a low pH that excludes other pathogenic microorganisms. Additionally, the innate immunity of the host and metabolic interactions between cervicovaginal microbiota, such as the production of bacteriocins and the use of proteolytic enzymes, exerts a profound influence on microbial populations, activities, and host immune responses. These interplays collectively impact pregnancy outcomes. This review aims to summarize the complexity of cervicovaginal environment and microbiota dynamics, and associations with bacterial vaginosis and sPTB. There is also consideration on how probiotics may mitigate the risk of sPTB and bacterial vaginosis.
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影响因子：
4.6
作者：
通讯作者：
--
影响因子：
4.5
作者：
Juliana NCA;Deb S;Juma MH;Poort L;Budding AE;Mbarouk A;Ali SM;Ouburg S;Morré SA;Sazawal S;Ambrosino E
通讯作者：
Ambrosino E
DOI：
10.1007/s43032-021-00711-2
发表时间：
2022-03
期刊：
Reproductive sciences (Thousand Oaks, Calif.)
影响因子：
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作者：
Amabebe E;Anumba DOC
通讯作者：
Anumba DOC
影响因子：
16.6
作者：
Chan D;Bennett PR;Lee YS;Kundu S;Teoh TG;Adan M;Ahmed S;Brown RG;David AL;Lewis HV;Gimeno-Molina B;Norman JE;Stock SJ;Terzidou V;Kropf P;Botto M;MacIntyre DA;Sykes L
通讯作者：
Sykes L
影响因子：
5.2
作者：
Anton L;Sierra LJ;DeVine A;Barila G;Heiser L;Brown AG;Elovitz MA
通讯作者：
Elovitz MA