Microbial diversity in the vaginal microbiota and its link to pregnancy outcomes.
Microbial diversity in the vaginal microbiota and its link to pregnancy outcomes.
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DOI：
10.1038/s41598-023-36126-z
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发表时间：
2023-06-04
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
阴道微生物群是指存在于阴道内的微生物。这些微生物对女性的生殖和整体健康有重大贡献。健康的阴道微生物群通常是一个低多样性的环境，以产乳酸的乳杆菌种为主。抗生素使用、性活动和荷尔蒙变化等因素可能会破坏阴道微生物群的平衡，导致细菌性阴道病等疾病。阴道微生物群的组成在怀孕期间发生变化并变得更加重要，作为母亲和胎儿抵御感染的屏障。尽管寄居在阴道的微生物很重要，但人们对成分和多样性的变化如何影响妊娠结局的细节却知之甚少。对于阴道加德纳菌患病率较高的女性来说尤其如此。在此，我们报告了 InSPIRe 队列中 749 名不同女性在妊娠最后三个月的情况。我们表明，包括卷曲乳杆菌在内的乳杆菌对于维持低多样性非常重要，并且这一关键群落的消耗与早产有关。我们进一步证明，提供最佳风险指标的是阴道微生物群的整体多样性，而不是特定物种。
The vaginal microbiota refers to the microorganisms that reside in the vagina. These microorganisms contribute significantly to a woman’s reproductive and general health. A healthy vaginal microbiota is typically a low-diversity environment with a predominance of lactic acid-producing Lactobacillus species. Factors such as antibiotic use, sexual activity, and hormonal changes can disrupt the balance of the vaginal microbiota, leading to conditions such as bacterial vaginosis. The composition of the vaginal microbiota changes and takes on added importance during pregnancy, serving as a barrier against infection for both mother and fetus. Despite the importance of the microorganisms that colonize the vagina, details of how changes in composition and diversity can impact pregnancy outcomes is poorly understood. This is especially true for woman with a high prevalence of Gardnerella vaginalis. Here we report on a diverse cohort of 749 women, enrolled in the InSPIRe cohort, during their final trimester of pregnancy. We show that Lactobacilli, including L. crispatus are important in maintaining low diversity, and that depletion in this critical community is linked with preterm delivery. We further demonstrate that it is overall diversity of the vaginal microbiota, not specific species, which provides the best indicator of risk.
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影响因子：
3.7
作者：
Dols JA;Molenaar D;van der Helm JJ;Caspers MP;de Kat Angelino-Bart A;Schuren FH;Speksnijder AG;Westerhoff HV;Richardus JH;Boon ME;Reid G;de Vries HJ;Kort R
通讯作者：
Kort R
影响因子：
7.7
作者：
Beghini F;McIver LJ;Blanco-Míguez A;Dubois L;Asnicar F;Maharjan S;Mailyan A;Manghi P;Scholz M;Thomas AM;Valles-Colomer M;Weingart G;Zhang Y;Zolfo M;Huttenhower C;Franzosa EA;Segata N
通讯作者：
Segata N
影响因子：
2.6
作者：
Farage, Miranda;Maibach, Howard
通讯作者：
Maibach, Howard
影响因子：
2.3
作者：
Austin MN;Rabe LK;Srinivasan S;Fredricks DN;Wiesenfeld HC;Hillier SL
通讯作者：
Hillier SL
影响因子：
4.4
作者：
Harwich, Michael D., Jr.;Alves, Joao M.;Jefferson, Kimberly K.
通讯作者：
Jefferson, Kimberly K.