Filtering and storage working memory networks in younger and older age
Filtering and storage working memory networks in younger and older age
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过滤和存储年轻和老年的工作记忆网络
DOI：
10.1002/brb3.544
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发表时间：
2016
影响因子：
3.1
通讯作者：
Müller NG
中科院分区：
文献类型：
--
作者：
Vellage A-K;Becke A;Strumpf H;Baier B;Schönfeld MA;Müller NG
工作记忆（WM）是一个多组分模型，其中包括过滤和存储两个过程。前者反映了抑制不相关信息进入内存的必要性，而后者指的是在内存中主动维护对象表征。在这项研究中，我们的目标是：a)通过避免先前研究的缺陷，重新定义视觉工作记忆中维持过滤和存储的神经网络；b)评估这些网络中与年龄相关的变化。方法设计了一个严格控制知觉负荷的新范式，在三种条件下分别呈现相同数量的刺激。在年轻（n= 40）和年长（n= 38）参与者的大样本中，我们分别计算了基线条件（低滤波和低存储负荷）和对滤波和存储提出高要求的条件之间的fMRI对比。结果我们的组间对比方法揭示了比以往研究更广泛的过滤和存储WM网络。在年轻的一组中，过滤涉及到双侧脑岛、右侧枕叶皮层、右侧脑干和右侧小脑。在老年组中，滤过与双侧脑岛、右侧楔前叶和双侧腹内侧前额叶皮层有关。在年轻参与者的双侧后顶叶皮层、左侧腹内侧前额叶皮层和右侧楔前叶皮层中也发现了广泛的神经网络。除了这些大脑区域外，老年参与者还调动了双侧前额叶腹侧皮层、上、中、下皮层和颞叶皮层、左扣带和双侧海马旁皮层。总的来说，与年轻参与者相比，年长参与者招募了更多的大脑区域，以达到相似的准确性水平。此外，老年参与者的一个大脑区域在两种对比中都出现了，即左侧腹内侧前额叶皮层。因此，年长的参与者似乎经常在高要求的任务中使用这个大脑区域，而不管过滤或存储是否受到挑战。
IntroductionWorking memory (WM) is a multi‐component model that among others involves the two processes of filtering and storage. The first reflects the necessity to inhibit irrelevant information from entering memory, whereas the latter refers to the active maintenance of object representations in memory. In this study, we aimed at a) redefining the neuronal networks sustaining filtering and storage within visual working memory by avoiding shortcomings of prior studies, and b) assessing age‐related changes in these networks.MethodsWe designed a new paradigm that strictly controlled for perceptual load by presenting the same number of stimuli in each of three conditions. We calculated fMRI contrasts between a baseline condition (low filter and low storage load) and conditions that posed high demands on filtering and storage, respectively, in large samples of younger (n= 40) and elder (n= 38) participants.ResultsOur approach of comparing contrasts between groups revealed more extensive filter and storage WM networks than previous studies. In the younger group, filtering involved the bilateral insulae, the right occipital cortex, the right brainstem, and the right cerebellum. In the elder group, filtering was associated with the bilateral insulae, right precuneus, and bilateral ventromedial prefrontal cortex. An extensive neuronal network was also found during storage of information in the bilateral posterior parietal cortex, the left ventromedial prefrontal cortex, and the right precuneus in the younger participants. In addition to these brain regions, elder participants recruited the bilateral ventral prefrontal cortex, the superior, middle and inferior and temporal cortex, the left cingulum and the bilateral parahippocampal cortex.ConclusionsIn general, elder participants recruited more brain regions in comparison to younger participants to reach similar accuracy levels. Furthermore, in elder participants one brain region emerged in both contrasts, namely the left ventromedial prefrontal cortex. Hence, elder participants seem to routinely recruit this brain region in demanding tasks, irrespective of whether filtering or storing is challenged.
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影响因子：
11.2
作者：
Baier, Bernhard;Mueller, Notger G.;Dieterich, Marianne
通讯作者：
Dieterich, Marianne
影响因子：
5.7
作者：
Groussard, M.;Rauchs, G.;Platel, H.
通讯作者：
Platel, H.
通过 SDS 聚丙烯酰胺凝胶电泳和电子显微镜分析发育中鸡心的收缩蛋白。
DOI：
--
发表时间：
1983
期刊：
Journal of embryology and experimental morphology
影响因子：
--
作者：
Lim,SS;Woodroofe,MN;Lemanski,LF
通讯作者：
Lemanski,LF
DOI：
10.1523/jneurosci.2245-09.2009
发表时间：
2009-09-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Olsen RK;Nichols EA;Chen J;Hunt JF;Glover GH;Gabrieli JD;Wagner AD
通讯作者：
Wagner AD
影响因子：
3.3
作者：
Bockova, M.;Chladek, J.;Rektor, I.
通讯作者：
Rektor, I.