Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways.
Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways.
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DOI：
10.3390/antiox11010003
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发表时间：
2021-12-21
期刊：
影响因子：
--
通讯作者：
Vachharajani V
中科院分区：
文献类型：
--
作者：
Gandhirajan A;Roychowdhury S;Vachharajani V
败血症和感染性休克是美国住院患者的主要死亡原因。脓毒症的免疫反应从促炎和促氧化的超炎症过渡到抗炎和细胞保护的低炎阶段。虽然1/3的败血症相关死亡发生在高炎症期间，但绝大多数败血症死亡发生在低炎症期间。过度炎症对免疫细胞有细胞毒性，不能持续。作为一种代偿机制，免疫细胞从细胞毒性高炎状态转变为具有抗炎/免疫抑制状态的细胞保护性低炎状态。然而，炎症减退与无法清除入侵的病原体有关，从而使宿主容易受到继发感染。因此，在脓毒症阶段，不适应的免疫反应导致明显的动态平衡偏离。从高炎症到低炎症的转变是通过表观遗传编程实现的。Sirtuins是一个高度保守的组蛋白脱乙酰化蛋白家族，也是体内平衡的守护者，是脓毒症表观遗传程序的组成部分。通过其抗炎和抗氧化特性，sirtuins调节脓毒症的免疫反应。我们回顾了sirtuins在脓毒症期间协调氧化应激和表观遗传编程之间的相互作用中的作用。
Sepsis and septic shock are the leading causes of death among hospitalized patients in the US. The immune response in sepsis transitions from a pro-inflammatory and pro-oxidant hyper-inflammation to an anti-inflammatory and cytoprotective hypo-inflammatory phase. While 1/3rd sepsis-related deaths occur during hyper-, a vast majority of sepsis-mortality occurs during the hypo-inflammation. Hyper-inflammation is cytotoxic for the immune cells and cannot be sustained. As a compensatory mechanism, the immune cells transition from cytotoxic hyper-inflammation to a cytoprotective hypo-inflammation with anti-inflammatory/immunosuppressive phase. However, the hypo-inflammation is associated with an inability to clear invading pathogens, leaving the host susceptible to secondary infections. Thus, the maladaptive immune response leads to a marked departure from homeostasis during sepsis-phases. The transition from hyper- to hypo-inflammation occurs via epigenetic programming. Sirtuins, a highly conserved family of histone deacetylators and guardians of homeostasis, are integral to the epigenetic programming in sepsis. Through their anti-inflammatory and anti-oxidant properties, the sirtuins modulate the immune response in sepsis. We review the role of sirtuins in orchestrating the interplay between the oxidative stress and epigenetic programming during sepsis.
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影响因子：
120.7
作者：
Boomer, Jonathan S.;To, Kathleen;Chang, Kathy C.;Takasu, Osamu;Osborne, Dale F.;Walton, Andrew H.;Bricker, Traci L.;Jarman, Stephen D., II;Kreisel, Daniel;Krupnick, Alexander S.;Srivastava, Anil;Swanson, Paul E.;Green, Jonathan M.;Hotchkiss, Richard S.
通讯作者：
Hotchkiss, Richard S.
影响因子：
3.1
作者：
Arnalich, F;Garcia-Palomero, E;Montiel, C
通讯作者：
Montiel, C
DOI：
10.1097/shk.0000000000000463
发表时间：
2016-03
期刊：
Shock (Augusta, Ga.)
影响因子：
--
作者：
Arulkumaran N;Deutschman CS;Pinsky MR;Zuckerbraun B;Schumacker PT;Gomez H;Gomez A;Murray P;Kellum JA;ADQI XIV Workgroup
通讯作者：
ADQI XIV Workgroup
影响因子：
3.7
作者：
Jung SB;Kim CS;Kim YR;Naqvi A;Yamamori T;Kumar S;Kumar A;Irani K
通讯作者：
Irani K
影响因子：
16
作者：
Cohen-Armon, Malka;Visochek, Leonid;Seger, Rony
通讯作者：
Seger, Rony