No evidence that carotenoid pigments boost either immune or antioxidant defenses in a songbird.

No evidence that carotenoid pigments boost either immune or antioxidant defenses in a songbird.
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DOI:
10.1038/s41467-018-02974-x
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发表时间:
2018-02-05
影响因子:
16.6
通讯作者:
Hill GE
Hill GE
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Koch RE;Kavazis AN;Hasselquist D;Hood WR;Zhang Y;Toomey MB;Hill GE

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膳食类胡萝卜素已被提出来增强脊椎动物的免疫系统和抗氧化功能,但旨在测试类胡萝卜素这些生理功能的研究往往未能找到支持。在这里,我们将黄色金丝雀(Serinus canaria),其中具有高水平的类胡萝卜素在其组织中,和白色隐性金丝雀,其中具有敲低突变,导致在非常低的组织类胡萝卜素水平,氧化和病原体的挑战。在不同的措施的生理表现,我们检测到类胡萝卜素丰富的黄色和类胡萝卜素缺乏的白色金丝雀之间没有差异。这些结果进一步挑战了类胡萝卜素直接参与支持脊椎动物生理功能的假设。虽然一些饮食类胡萝卜素提供间接的好处,类维生素A的前体,我们的观察表明,类胡萝卜素本身可能在鸟类的关键生理过程中发挥很少或没有直接作用。膳食类胡萝卜素除了有助于着色外,还具有生理益处。在这里,Koch等人比较了富含类胡萝卜素的黄色金丝雀与缺乏类胡萝卜素的白色金丝雀的免疫和抗氧化功能,没有发现差异,表明类胡萝卜素的生理作用有限。
Dietary carotenoids have been proposed to boost immune system and antioxidant functions in vertebrate animals, but studies aimed at testing these physiological functions of carotenoids have often failed to find support. Here we subject yellow canaries (Serinus canaria), which possess high levels of carotenoids in their tissue, and white recessive canaries, which possess a knockdown mutation that results in very low levels of tissue carotenoids, to oxidative and pathogen challenges. Across diverse measures of physiological performance, we detect no differences between carotenoid-rich yellow and carotenoid-deficient white canaries. These results add further challenge to the assumption that carotenoids are directly involved in supporting physiological function in vertebrate animals. While some dietary carotenoids provide indirect benefits as retinoid precursors, our observations suggest that carotenoids themselves may play little to no direct role in key physiological processes in birds. Dietary carotenoids have been proposed to have physiological benefits in addition to contributing to coloration. Here, Koch et al. compare immune and antioxidant functions in yellow, carotenoid-rich vs. white, carotenoid-deficient canaries and find no difference, suggesting a limited physiological role of carotenoids.
实验性育雏尺寸的操纵和性别对欧亚kestrels falco tinnunculus的类胡萝卜素水平的影响。
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