Nanomedicine therapeutic approaches to overcome cancer drug resistance.
Nanomedicine therapeutic approaches to overcome cancer drug resistance.
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DOI：
10.1016/j.addr.2013.09.019
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发表时间：
2013-11
影响因子：
16.1
通讯作者：
Ljubimova JY
中科院分区：
文献类型：
--
作者：
Markman JL;Rekechenetskiy A;Holler E;Ljubimova JY
纳米医学是一种新兴的治疗形式，其重点是替代药物输送和提高治疗效果，同时减少对正常组织的有害副作用。肿瘤耐药是一个涉及多种机制的复杂过程。在这里，我们讨论了耐药性的主要形式和纳米医学提供的新的可能性，以克服这些治疗障碍。可以创建基于肿瘤遗传特征的具有高度灵活，快速药物设计和生产能力的新型纳米药物，使个人患者治疗的药物选择更加密集和有效。本文综述了纳米医学这一新兴医学领域在克服肿瘤耐药性方面的优势。随着先进的设计和替代机制的药物输送已知不同的纳米药物，包括脂质体，聚合物共轭物，胶束，树枝状聚合物，碳基，和金属纳米粒子，克服各种形式的多药耐药性看起来很有希望，并开辟了新的视野癌症治疗。与游离药物相比，纳米颗粒的多药耐药性和肿瘤蓄积的规避。
Nanomedicine is an emerging form of therapy that focuses on alternative drug delivery and improvement of the treatment efficacy while reducing detrimental side effects to normal tissues. Cancer drug resistance is a complicated process that involves multiple mechanisms. Here we discuss the major forms of drug resistance and the new possibilities that nanomedicines offer to overcome these treatment obstacles. Novel nanomedicines that have a high ability for flexible, fast drug design and production based on tumor genetic profiles can be created making drug selection for personal patient treatment much more intensive and effective. This review aims to demonstrate the advantage of the young medical science field of nanomedicine for overcoming cancer drug resistance. With the advanced design and alternative mechanisms of drug delivery known for different nanodrugs including liposomes, polymer conjugates, micelles, dendrimers, carbon-based, and metallic nanoparticles, overcoming various forms of multi-drug resistance looks promising and opens new horizons for cancer treatment. Evasion of multidrug resistance and tumor accumulation of nanoparticles in comparison to free drug.
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DOI：
10.1016/j.jconrel.2013.06.001
发表时间：
2013-11-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Ding H;Helguera G;Rodríguez JA;Markman J;Luria-Pérez R;Gangalum P;Portilla-Arias J;Inoue S;Daniels-Wells TR;Black K;Holler E;Penichet ML;Ljubimova JY
通讯作者：
Ljubimova JY
影响因子：
3
作者：
Daniels, Tracy R.;Bernabeu, Ezequiel;Rodriguez, Jose A.;Patel, Shabnum;Kozman, Maggie;Chiappetta, Diego A.;Holler, Eggehard;Ljubimova, Julia Y.;Helguera, Gustavo;Penichet, Manuel L.
通讯作者：
Penichet, Manuel L.
影响因子：
14
作者：
Burke, Andrew R.;Singh, Ravi N.;Carroll, David L.;Wood, James C. S.;D'Agostino, Ralph B., Jr.;Ajayan, Pulickel M.;Torti, Frank M.;Torti, Suzy V.
通讯作者：
Torti, Suzy V.
DOI：
10.1073/pnas.1003919107
发表时间：
2010-10-19
影响因子：
11.1
作者：
Ding, Hui;Inoue, Satoshi;Ljubimova, Julia Y.
通讯作者：
Ljubimova, Julia Y.
影响因子：
8.8
作者：
Davies, CD;Berk, DA;Jain, RK
通讯作者：
Jain, RK