Estimating the community prevalence, child traits, and maternal risk factors of fetal alcohol spectrum disorders (FASD) from a random sample of school children.
Estimating the community prevalence, child traits, and maternal risk factors of fetal alcohol spectrum disorders (FASD) from a random sample of school children.
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DOI：
10.1016/j.drugalcdep.2021.108918
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发表时间：
2021-10-01
影响因子：
4.2
通讯作者：
Hoyme HE
中科院分区：
文献类型：
--
作者：
May PA;Hasken JM;Hooper SR;Hedrick DM;Jackson-Newsom J;Mullis CE;Dobyns E;Kalberg WO;Buckley D;Robinson LK;Abdul-Rahman O;Adam MP;Manning MA;Jewett T;Hoyme HE
利用随机样本来估计美国东南部县胎儿酒精谱系障碍 (FASD) 的患病率、儿童特征和孕产妇风险。从所有一年级学生 (n=1073) 中抽取了一个简单的随机样本，其中 32% (n=231) 表示同意。所有 231 名儿童均接受了畸形和生长检查，84 名儿童接受了神经行为测试和评估，72 名母亲接受了产妇风险访谈。诊断为 FASD 的儿童与整个样本的身体特征之间的显着差异 (α=.05) 为：身高、体重、头围、体重指数和总畸形评分，以及胎儿酒精综合征的所有三个主要特征、睑裂长度、光滑人中和狭窄朱红。 FASD 和功能正常的儿童之间的智力功能和抑制没有显着差异，但两项执行功能测量和一项视觉/空间测量接近显着性 (α=.10)。胎儿酒精谱系谱系障碍（FASD）组的三项行为指标明显较差：父母认为的沟通、日常生活和社交问题。据报道，重要的孕产妇危险因素包括产后抑郁症、饮酒频率以及饮酒问题的恢复。 FASD 的患病率为每 1,000 人 71.4 人，即 7.1%。这一比率显然落在美国四个地区 FASD 患病率合作 (CoFASP) 研究中其他社区八个较大样本确定的患病率范围内。对小规模随机样本中的儿童进行仔细、详细的临床评估可有助于估计社区中 FASD 的患病率和特征。
Utilize a random sample to estimate the prevalence, child traits, and maternal risk for fetal alcohol spectrum disorders (FASD) in a Southeastern United States county. From all first-grade students (n=1073) a simple random sample was drawn, and 32% (n=231) were consented. All 231 children were examined for dysmorphology and growth, 84 were tested and rated on neurobehavior, and 72 mothers were interviewed for maternal risk. Significant differences (α=.05) between the physical traits of children diagnosed with FASD and the entire sample were: height, weight, head circumference, body mass index, and total dysmorphology scores, and all three cardinal features of fetal alcohol syndrome, palpebral fissure length, smooth philtrum, and narrow vermilion. Intellectual function and inhibition were not significantly different between FASD and typically-functioning children, but two executive function measures and one visual/spatial measure approached significance (α=.10). Three behavioral measures were significantly worse for the FASD group: parent-rated problems of communication, daily living, and socialization. Significant maternal risk factors reported were postpartum depression, frequency of drinking, and recovery from problem drinking. The prevalence of FASD was 71.4 per 1,000 or 7.1%. This rate falls clearly within the prevalence range identified in eight larger samples of other communities in the Collaboration on FASD Prevalence (CoFASP) study in four regions of the United States. Careful and detailed clinical evaluation of children from small random samples can be useful for estimating the prevalence and traits of FASD in a community.
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影响因子：
8
作者：
Hoyme, H. Eugene;Kalberg, Wendy O.;May, Philip A.
通讯作者：
May, Philip A.
影响因子：
6
作者：
Kaskutas, LA;Graves, K
通讯作者：
Graves, K
影响因子：
3.4
作者：
Burd, L;Cox, C;Klug, MG
通讯作者：
Klug, MG
影响因子：
2.3
作者：
Hannigan, John H.;Chiodo, Lisa M.;Delaney-Black, Virginia
通讯作者：
Delaney-Black, Virginia
影响因子：
3.8
作者：
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通讯作者：
Lindemann, Rolf